ID   A0A369JT81_HYPMA        Unreviewed;       369 AA.
AC   A0A369JT81;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE            EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
GN   Name=SPBC119.15 {ECO:0000313|EMBL:RDB21936.1};
GN   ORFNames=Hypma_011087 {ECO:0000313|EMBL:RDB21936.1};
OS   Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX   NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB21936.1, ECO:0000313|Proteomes:UP000076154};
RN   [1] {ECO:0000313|EMBL:RDB21936.1, ECO:0000313|Proteomes:UP000076154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=51987-8 {ECO:0000313|EMBL:RDB21936.1,
RC   ECO:0000313|Proteomes:UP000076154};
RA   Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA   Jeong J., Song E.-S.;
RT   "Whole genome sequencing of Hypsizygus marmoreus.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC       polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC       nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC   -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC       Nucleus {ECO:0000256|RuleBase:RU365059}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC       {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDB21936.1}.
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DR   EMBL; LUEZ02000053; RDB21936.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369JT81; -.
DR   STRING; 39966.A0A369JT81; -.
DR   InParanoid; A0A369JT81; -.
DR   OrthoDB; 5475185at2759; -.
DR   Proteomes; UP000076154; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd17870; GPN1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR   PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365059};
KW   GTP-binding {ECO:0000256|RuleBase:RU365059};
KW   Hydrolase {ECO:0000256|RuleBase:RU365059};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU365059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076154}.
FT   REGION          304..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..335
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  41473 MW;  C9E5F1007E7BCD38 CRC64;
     MEASSSSTKR KPTAIITIGM AGAGKSTFVQ RINSYLHSLD PPSPPYILNL DPAVTHVPFE
     ANIDIRDTVN YAEVMKQYNL GPNGGILTAL NLFTTKFDQV LGLVEKRAAE VDYVILDTPG
     QIEIFTWSAS GAIITDAVAS SMPTVVAYII DTPRTTAPAT FMSNMLYACS ILYKTKLPFI
     LVFNKTDVQP HDFALEWMQD FEEFQAALAS HSSSRDSEGE PTYMNSLMNS MSLVLDEFYK
     NLKAVGVSSM TGDGIKEFFE AVEASREEYE KDYLPELERA RAQREKTLQD AKDDSMDRLM
     KDLEIDRAKN PQGALNDRWD PDEENDEDDD DDTDINIVDR SEHPWPGQYI DVTRARRHED
     EGINWPRPG
//