ID A0A369JVW3_HYPMA Unreviewed; 926 AA.
AC A0A369JVW3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=CLCN5 {ECO:0000313|EMBL:RDB25370.1};
GN ORFNames=Hypma_007866 {ECO:0000313|EMBL:RDB25370.1};
OS Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB25370.1, ECO:0000313|Proteomes:UP000076154};
RN [1] {ECO:0000313|EMBL:RDB25370.1, ECO:0000313|Proteomes:UP000076154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=51987-8 {ECO:0000313|EMBL:RDB25370.1,
RC ECO:0000313|Proteomes:UP000076154};
RA Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA Jeong J., Song E.-S.;
RT "Whole genome sequencing of Hypsizygus marmoreus.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDB25370.1}.
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DR EMBL; LUEZ02000041; RDB25370.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369JVW3; -.
DR STRING; 39966.A0A369JVW3; -.
DR InParanoid; A0A369JVW3; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000076154; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000076154};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 425..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 499..518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 601..622
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 628..650
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 869..926
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 101905 MW; 2E6A5598DC59127B CRC64;
MPNSPAPGSH GPSVGPSSTT WRRERLLRIG SSNTVNTFPE PGHPETPTTL NTPDLTPTEH
TSLQSRGASY GTLPLPRRRP SNKPSLNLSY RGVSPLRNLN FLHRAVSIPS AGFKDLAFSR
LSLQRPISSY DAPLKSDVEP DADAKINGIR VWYSSFSSID WLHDAIKDSV RFSRLRRRKS
LRARIRLATD KSLGWVVVTI VGFLTAVVAF LVVRSELWLF DTKEGYCRDS WWKAKRFCCP
NASEIHSVPG AFPYSREVSC NEWNTWADVF AKGESGIRTD AIEYISYSLI ALSLALTSSL
LTIYLTNSTT FITRKESGVL APDFLSSTNR PKAQETAAVS KRKVMYYAAG SGIPEIKTIL
SGFVIHGYLG GRTLFTKAVG LALSVASGLS LGKEGPFVHI ASCVGNIVSR FFSKYENNEA
KRREILSAAC AAGVAVAFGA PIGGTLFSLE EVSYFFPPKV MWRSFFCAMI AAITLKMLDP
FGTGKLVLFQ VTYDKDWHAY ELLPFVLLGV FGGVYGAYFS KLNHSWSKHV RNKTWLKTHP
ILEVLLITLI TSILCFVNPY TRMSGTELVY NLFAECRTGS GNSHSGLCVL DPSTFKNIWP
VIRAILVAMI VKAGLTVVTF GIKVPAGIFI PSLGVGACAG RVMGIAMQWL QWQRPALGMF
SACGGGDMDC IIPGLYAMVG AAATLSGVTR TTVSLAVIMF ELTDTLTYAV PVMLSVLVAK
TVADALEPKG IYDLVIELNQ LPYLDSKHEY LWGKLQINDV TARDVEVIRL DRKNTVMSLR
DQLFTLTASG NDDSGFPILR RDINDDGMRM VGYIGSNELE HALSIVADEA EDEVHFHTTY
SHNMAASSIS SLSEELGRSK DIFDFSDYMD QAPLTVQSNS PLEMVHQFFS KLGARYVVVT
DTEGIYEGVI DKKTWVAFLA DLEEKS
//
