ID   A0A369K452_HYPMA        Unreviewed;       672 AA.
AC   A0A369K452;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Adenosine deaminase-like protein {ECO:0000313|EMBL:RDB27425.1};
GN   Name=adal {ECO:0000313|EMBL:RDB27425.1};
GN   ORFNames=Hypma_004288 {ECO:0000313|EMBL:RDB27425.1};
OS   Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX   NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB27425.1, ECO:0000313|Proteomes:UP000076154};
RN   [1] {ECO:0000313|EMBL:RDB27425.1, ECO:0000313|Proteomes:UP000076154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=51987-8 {ECO:0000313|EMBL:RDB27425.1,
RC   ECO:0000313|Proteomes:UP000076154};
RA   Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA   Jeong J., Song E.-S.;
RT   "Whole genome sequencing of Hypsizygus marmoreus.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine;
CC         Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842;
CC         Evidence={ECO:0000256|ARBA:ARBA00036622};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002;
CC         Evidence={ECO:0000256|ARBA:ARBA00036622};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDB27425.1}.
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DR   EMBL; LUEZ02000017; RDB27425.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369K452; -.
DR   STRING; 39966.A0A369K452; -.
DR   InParanoid; A0A369K452; -.
DR   Proteomes; UP000076154; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR022226; DUF3752.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF42; ADENOSINE DEAMINASE-LIKE PROTEIN; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   Pfam; PF12572; DUF3752; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000076154}.
FT   DOMAIN          26..332
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
FT   DOMAIN          514..664
FT                   /note="DUF3752"
FT                   /evidence="ECO:0000259|Pfam:PF12572"
FT   REGION          355..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..371
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        530..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..603
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..643
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   672 AA;  74020 MW;  E2B4E5ECE9A89602 CRC64;
     MAIAGPAGEA LRSLTEDQVK FIKTLPKAEL HAHLNGSIPI SVLQDLAREY VSSGAPPVSE
     TGLSNEAIQA AMNRLLDGPT LDEISHFFTL FPAIYALTST PEALARATRA VLSEFLDGEY
     PQCTYLELRS TPKETLTMSR EKYVRVVLGE LARYGVQRVG LVVSLDRRMG EDVLRECLDV
     AKKLKGEGEP VVGVDLCGDP MAGDMASFQK YFEEAKSAGL GVTLHIAETV NNPASETLQL
     LSFSPDRLGH ATFLDDVAKK LVAEQNTCVE ICLTSNLLCK TVPTLDDHHI NHYLRENHPI
     AICTDDILPF RTSLVGEYAL LMAQPPLGFG MSEDELIQVG TRDIVLIGPE LPSHLHKQNK
     EEQEDDIDKI TSIRPVIPSE PLNATKPADD EEDDEDDYVP ALPPDMVAMR SAGPSNSVLP
     TSTQSSSNSS TSKRVVGPSL PSYPPTYDPM FHSSYAEDDD DDDDFGPKPL PAGVRHAETD
     AVKEFMEREE RRRKEAEEAA KPKALKRDEW MLVPPTSSDL LGNLDPTKLK ARQFSRSTAP
     AVKKQDNSLW TETPAERQQR LADEVSGKKR RAADPKVEEE SDERKRRRMD EDVIRKGVDE
     YTQKRRGPAL MAQHAASGKA EPSKDKEGGI WDHSRDMSLG GRLMDDEKRG KLVREAAGLG
     DRFGTAKSGG FL
//