ID A0A369RRD9_9METZ Unreviewed; 1282 AA.
AC A0A369RRD9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN ORFNames=TrispH2_011070 {ECO:0000313|EMBL:RDD36871.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD36871.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD36871.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD36871.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD36871.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD36871.1}.
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DR EMBL; NOWV01000302; RDD36871.1; -; Genomic_DNA.
DR STRING; 287889.A0A369RRD9; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15040; 7tmB2_Adhesion; 1.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RDD36871.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1282
FT /note="Latrophilin Cirl"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016621352"
FT TRANSMEM 943..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1000..1027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1047..1071
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1157..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..161
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 941..1181
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1282 AA; 140968 MW; FDE9120EF8DACC35 CRC64;
MFIDEIMTID TLTILCLILT ILNSTAMNGQ EVCTPGWTKI SNRCFKSFEI RTTYGIARSS
CQQMSGDLAV DDSVIIHNAL YNLLLKHKPY WIGLEKRYGD NLTSDYRWLA TGQSVIHGPQ
FWANSNPVDG PDRCVFIIKV NGFHSYWRNK NCSYLHRYIC QKSAEEVSLS SIPVVSISVE
NTDPPTTELN PLYSITSQVD VGTSKIDSSS PSITLSSNTN IFSSPLPVTS TSVESKDASA
TEVYALTLTT SQVNIETSEI ASLSLSITLS SNSNILASTV NKLESSTSTD SNNNIISSLY
EDAVILSSPS SDFNVNISAS TDKDPLISSA SSFTLAIESL TSIDSKVYIS SSADENPLIS
SISSSVFILD HNLRVVLTVN TAMSDSERFT SRNEQASSSS RSSNNALLTT SELSLLASTT
TDSFVSLSMH EDLSTSIVDK ETFVLDSQNL LSSLLTNSSF DNVIMATTAV GSQQIPSTTS
GLNINSTTFE DSLRPSILSS NFVINSALSI TSATPTVIIA EKGSDAYNQL VISSSWINSN
SEVIQLSTAT NHLPLTAYVT LQSHISSSIN EYSLMVLIID DIITNDASVT VTNVKDEGNA
TLHQQLSSNS SMQSSSTITI DTPTIANNSP LLSSNLSVSD PSLYNTKENL LSSLSDHGMT
GDYNTCITCN NRPGFTTMDI FQHPRTLSVT TIPPLEYSTS SSPVSANITL NQSSSADNES
YIANHVKASK MIDEIQETNS QLIVNITDTV DKNPGLILTQ IDKFDTNLAK KINQANITTQ
FRMSTPQSEL VAQTIKASNT KSTINLVLSS SNKSVAEVRI PKSAFQFSDQ DHTVTVVVRT
YNVERYWAEN NANGNNSIII SSILSCSVYP PQDKNFTVPV HLHFKIQYGQ TYPPYRCAYW
EQFGWSEYGI QLLGYNSTRV HCATSHFTSF AALTGPHDAN LRYITYAGYS ASLFALLVMI
TILISSKKFY TVKHFIHLNL AVAMVISIIG FLAGIHATQL PLLCTIIAVG LHFFYLASLT
WMMMEALLLL QKISSMRKTI DLKIRRLYFI AGWLPPAVIV AVATCTGIDA YRNSNNCWIK
NASPQMWFFV GPIILIVVSN IAITITAVKA LFSITVMVQK SEIQKFKVGI RAVTSLIFLF
GVSWLFGILY YATDNIAFAY LFTVLNCPQG LLIFYFHCFR DHDVQEYFQK RTKFGTMIFP
MQSMRDTSGE TRSEDTRASR NVKIPLLPLS TDNISCNSVD IRRDSKSLNK IQEMCSSYSV
TTMASVCDHS GIWTNRKKSG FN
//
