ID A0A369RRM9_9METZ Unreviewed; 1576 AA.
AC A0A369RRM9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN ORFNames=TrispH2_011054 {ECO:0000313|EMBL:RDD36892.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD36892.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD36892.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD36892.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD36892.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD36892.1}.
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DR EMBL; NOWV01000299; RDD36892.1; -; Genomic_DNA.
DR STRING; 287889.A0A369RRM9; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15040; 7tmB2_Adhesion; 1.
DR CDD; cd00037; CLECT; 3.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 5.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 3.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00034; CLECT; 5.
DR SUPFAM; SSF56436; C-type lectin-like; 5.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 5.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RDD36892.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1294..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1361..1378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1398..1417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1437..1459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1480..1503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1509..1528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..187
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 223..347
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 359..463
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 511..609
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 611..736
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1295..1533
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1576 AA; 174118 MW; 400B036648DBD211 CRC64;
MVRAKLSVFQ CVVFVIVADF IPVLSNYSSI FACGIPCAIL PSTSLAENDY GHTKVSVADD
LWYSHNSKRY FFSQTTLTFQ AAVNYCRDTY GGSLLEISGH NENTVIRNML ISENAPSAIF
WIGIQDSSGI FANAVWHHSN ASVGDWNLWY QDIVVDPSKL CTGGFEIFGT FVWKNLRCSD
PYRFICQIDL NTTTSNFILA SYLFASYPRP PHENVCKAPN IVFNNTCLSP HNTLLPFNLS
INYCKAIGKR LLQVESQAKS QVLNSIISST MEVWIGLRSH LSKSVSKKDF TWLYDDPNLL
ASNFTAWEKF TPITINNPIS GKCATIKRDS LLWKNRPCQS FYPFICQQEM TCPAGWLQFR
DSCYQVMNPY GVGTYWLGAF LSCKFSYSSG LAIIASKDEM KFIESVALSL NRPLWIAMKA
DGKGLRWNSK ENITNHYQIP PNAYCMLVKP TGNRVTWEFS SCSTGIGAYP LCQKAATPIT
LNNSEGLTTA AIVDSIGKDI FPTCPDNWLL YRNYCYYLET TTGNYLQGKN RCKNNLEAYP
AIINDAEKEM IIRSILGIDD EVWIGLEGTS NNFTWYENLA SINYTNLVAH ACYPENSCEL
QTNCPTDWNI NGVNCIQITF QKLRFYNARE FCSYHKSDLI SLSSIDLEQV TQNLIEQKAV
NQLVNITGVS FWIGLYKVNN TFQWLQDSTA VQENSKLEFR STAGTSQLRC AVMEYMHLNG
TWVWYTVDCV SHRAYLICRK TIDLESDTST FPMVQSTTQV PVTTEDSETG AISFAIDAVI
ANTEDSSTTD ISTNTIVTTP NISTTTTENS TTSNIFTTTS AVTAAVENST TLNVSATTNA
ATATTENSIT TKISITTSAA TAAVEDSTTL SIPAATNTAT ATTENSTTTK ISTTTSAATS
AVEDSTTLSI PAATNTATAT TENSTTTKIS TTTSAATAAL GDSTTPNIST TTNTATVTTE
NSTTKKISTT TNTTTATIED STTPTISTTN NAATLTTKDS KTVNISITTD AKTATIEDSP
IVNVSTTKNG VIATIEDSTI ANISVTTNVA TTTTEDSTTS SFSTATNNAV TTNTVPITKR
NPRTIKALTN IGTTTTTMLS TVSTLSTRVA TNRNQTYDNI DEVVDNAGLE LAGKLSLFAN
SNNSQVSYYY QKLEEVSAVQ ESDTGHPLKV KVPTSIIDNK YEGQFQIAIG IYKSTQFQQR
NRIQQPLKYA VSCQIRPIMK GTLKEPVVFF YEIKEGSNKQ PSCAYWKKNH WATDGLKLEK
INATTIKCLS YHLTSFSVLL RFNNYSSPKI HDKILSITTY IGLSISLLCL IVTFLTFTAI
RQFHSIRGLI HANMAASMII STTVFLLGIQ WTNSPAICKS IAAILHFSLL ATFLWMLIEG
IATFKMSTHN LESRNSSISY LLLGWGIPMV IVLISFLSGS TYYGTTTYCW IQPGKHLLYA
FGIPTSIIVC INVILMIRIA RSLVGIRAIA TKSNIQKVRA LLRASAALLP LLGITWVVGF
LAYNHQTLIL DYFFVILNSF QGVFIFYFHC YNYKGVKRYY ARRFIHSAYS PRNQISKASN
TDLMTRSKRR KSAWEG
//
