ID A0A369RRY9_9METZ Unreviewed; 765 AA.
AC A0A369RRY9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MAM and LDL-receptor class A domain-containing protein 2 {ECO:0000313|EMBL:RDD37229.1};
GN ORFNames=TrispH2_010597 {ECO:0000313|EMBL:RDD37229.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD37229.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD37229.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD37229.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD37229.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD37229.1}.
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DR EMBL; NOWV01000261; RDD37229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RRY9; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00108; KR; 1.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF146; ENDOSOMAL GLYCOPROTEIN PRECURSOR, PUTATIVE-RELATED; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF56487; SRCR-like; 2.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS50287; SRCR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RDD37229.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..155
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 201..276
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 294..340
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 343..444
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 688..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 369..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 382..443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 412..422
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 765 AA; 84533 MW; CE027B28FC9E9CAF CRC64;
MEYVMGSSSR KIVMLWFISM IILSASIIVE GVHESNRCQQ YREKRCQFNT SSVYSFSVPP
VYYTRCNFDS DTCGWNQLKN IDFFDWTRSK GSLPSAGTRS LYDHTQNNGS GFYMYIDASV
NNYGTYADLI SPPLQLSAVG DKIRISFYYH AFGSSLGELH VYAVYPRHEN AFHILLRGMV
GSTHSSNIAI DDISVLSVET SCYTSHGEFY RGTENYARNG SVCQNWHSFN LTTSYATANH
LMSNYCRNPF GSTRNHPWCF TDTLTRQWQY CNISRCNPLL IPTPAYPLGT PYPLSFVHNL
VEQTNVGRVV LYHNGQWGTI CRAGLKASTA ALMCQSFGIG TVGQLTSIGG NDTSGVIYVG
VNDRYGIICF SAWNLNSADV ACRQMGYIGA YSSNVTTSIY PTRSVLIDLI ECNGYESSIG
QCKALIVSSS SSCLSTSIAT ASCNSGQKSY TSNNKPSNCQ FEYGLCGWNT TGNPTWIWHP
AGTGRFAGFS NDMSYLQLVR PPGYANPITA VFSSPPFERI DTSVYITFRY ILNSHFSGVF
EIQYAMLTMQ YFDRIYHNAF TSADFNTWLS VTTTTFRPSS SSLFRINFFY KSPPTSSNSE
ISVIGLDDIR VYGVDGIHPS HAAHNLTRLG IGCGVGLTVL MFIIAYAYVV RYRRRLERGG
RSTIANVNLN GQGENGVVTA DTHFNGASMN SVQNLPPPSY PAAINSHATG ETPSSQSGCD
NNDHNSELGT NNLRYQVDSN SQLSTKSPAD PSLAPPTYDQ AASRQ
//
