ID A0A369RSZ0_9METZ Unreviewed; 1299 AA.
AC A0A369RSZ0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN ORFNames=TrispH2_011113 {ECO:0000313|EMBL:RDD36933.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD36933.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD36933.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD36933.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD36933.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD36933.1}.
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DR EMBL; NOWV01000293; RDD36933.1; -; Genomic_DNA.
DR STRING; 287889.A0A369RSZ0; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF08477; Roc; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 202..235
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 244..277
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 286..319
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 328..361
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 370..403
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1230..1297
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 1299 AA; 148895 MW; 5999B7280E9C46E4 CRC64;
MADDESVCST SVLPHHTRIQ SLYEKGNSCK TAFQLVDGLS CYTQAVDEIA SLSNPSADID
RLACDIYLGL CDIYTLQYKF MKAAEWSEKG QTVATNLQDE VSTAQCLQRE SEIKRCQGDY
NGALEDGKKS LEMKLKWLDE KDARLADSYY QIGRVYFDLC KLDLCRTISD KSLQIRLSVL
GHNHPDVANS YHNIGDVYRS LGNLYNNIGV VYDHQGKSDQ ALDIYDKSLQ IGLAVLGHNH
PYVAKSYNNI GVVYHRQGKY DQALDMYHKS LQIGLSVLGH NHPYVANSYK NIGVVYRNQG
KNDQALNMYD KTLQIRLSVL GHNHPYVAKT YDKIGVVYRS QGKYDQAVDL HDKSLQIRLS
VLGHNHPDVA NSYKNIAVVY HCQGKYDQAV DMYKKSLYIA ALNGNDRLVT RIRKNIEITL
QKQKSVIRDL STSIARNFIR SIVELFQPNQ TSNVTAPANT IDGSQNNQHI QQKALQEKKY
YNAYSKGLKH GHCFNHLIRG MFIGPRNVGK TSLRKIFTQQ RLNNPSPTQV AESLDIMVDT
EYYNIHNSEC CDWTEILDDK VKTVIQQLAQ PSIDRQDNIS QQVTDIDPID QPVIANNPPV
SNWQQHSVDS SATDVITQDV ALVGKEIPIE SQSKRGLHQY YCSSMESQNA DKDDKNQYVK
IWDFAGHAVY HVTHYPFISV NCIYILVFNI NQDINDKVRT RKNQSLKTTY LQAMQEWLTS
IIAGHTSQST INVNIKSGDE QHLPPSQHSL PIIILVASHG DCITNEKDGR TRFNQFVSTL
TSRMPSYASH IYSSGIIFDC NPLDSTPSTQ KLRQQCCLRL HGIIKAFVQS LPFITNPIPI
RWYIMATILN KSLPTNNQPA SSIMNQIRHS QVHNIMTMQQ IVTLSQQYGL YENRDELIAM
LMYLHDLGEV IYCDKVGDDG IIITNVDWLL SIFRSIIQLQ DFVQGSAQIK RDYDIASQTG
KLSRSYIDHA IYKFNLDDNS KQTILALMHA YDILCSITNE KNDNGEECQY FVPYLLRYDV
KPFDLSKYHQ SDWLYIGYEH TDIPYLPDGI YYCLLSSCLK EWNNTDVELY YQCAKYYLAN
DNHYLVVRKE ESHIGLQYCY QKINELKRSQ SIIDKVKNSI FVKRPHEIVK NKLISTVNDR
MVKFKGADCR YFVKCSECNT QTSITEEYKE GDQNWIRCKH CKMEFASQSL NDWMIYNEKF
WIEKKIYAED KERACFDLIA AKLNGTHIVR FGVLLKLTDT KINEIKSSQD EGRYDKVHNV
LKSWKDKAGM NAKISAVVEA LRKMEINALA DEVEKKMTE
//
