ID   A0A369RT44_9METZ        Unreviewed;      1305 AA.
AC   A0A369RT44;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Nephrocystin-3 {ECO:0000313|EMBL:RDD37412.1};
GN   ORFNames=TrispH2_010395 {ECO:0000313|EMBL:RDD37412.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD37412.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD37412.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD37412.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD37412.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD37412.1}.
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DR   EMBL; NOWV01000244; RDD37412.1; -; Genomic_DNA.
DR   STRING; 287889.A0A369RT44; -.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 4.
DR   SMART; SM00028; TPR; 9.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 4.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          123..156
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          165..198
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          291..324
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          377..410
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          1201..1284
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   1305 AA;  150428 MW;  7AE60E5CC92461A6 CRC64;
     MEIKLQRKEA NKLFKQGSYE EARSLYRQVL DRIGGSNVLP RFEITLQIVK TSIYLQDYEI
     AKSDCESAKL LARRLSDKKL LQCEKYLGEI CHQQGNHEDA LQYYNLAYRL SVQINGSKHL
     TTADISQQIG DVYVAMQHYS DALTSYKQAL KVRQKRLTKF SKLIANSYFA IGNVYSCERE
     YKLAITNFQE SLAIRHKLFE NNHLLIADCY ERLAQICNDQ CKFHEAASLF EKCLKIYLVV
     GGKTNFDVAQ LYRNIGLAKF DNGDHGEALS SHQKCLEICI NIYGEEHPNV AMSYSSLASI
     YYQQEEYQQA YDMFRKSLDI NLKVLGSNHW IIADTYHNIG NIHYNQEKCS DALKMYQVAM
     FMRLKQTRND HIRHRIADSY FVVANVYAKQ SKYHDALEMF LKSFSIFQNL YGESNIVAII
     YQKIAELYDR DGRADDANDM RSRASEIFDR LEHGQIPTPI QTTSPDVIVV VVIVENDYFK
     AYMIATIYEE CHSDCTRLTF IGPSDSGKNF IVKLLTKQNL TSPYVAENTE AMLDLSTGNI
     FKQKTDDYRK IVGKKIAATM LSITQQMESQ YKMEESSLSE LILSKIETVP EANPTIISSF
     TSEYDENRLE ERISNTDTNL NASPSTQYAS VDTRRYLDTF NDFMQQSLQL CDADNSQRSY
     YSNVWEFGSK ISWNLRQLFT LRNSIYILTL DITEATNQTS ATNEERTTLN TFLDSIKECL
     VSVLDGHCDD AISDPIQVDD ADLDVGIYEE FALPVVIFVG FHDDCVTSDT VRIFNNLTET
     IFSTFPQYSR HIIPSDVVFN CNPKDTSSYA IEQRETSCQA LRKLIQHFTK LMPVLQDRVP
     IRWHILLSIL HKSVINDGCA CSSNSSNFPR RVMSVHEVEE LLQDCGLFRS DQDTCKMLQH
     LHDLGEILYV KPDYGKEYII TQVEWLAKIF QVLFASAFGQ KADATRRFSF TRITKIKTDG
     IMKESHITNV LREFSLDDKE KEAILQLLEN YNIICPRNNA NANNESVAAA GREYFVPIII
     TPNFKSKIDI GSLNDAGYHV SESLYIQFED NSYIPDVIFY PFLISCLRKW NNLEAELFYR
     GAKLFLENDL YYLLIVKERS KISLRYFYKK STNLSDELIK KLVWKSRPQE LIQGRFFDTA
     KKYMPKSMNS SLANYVKCSE CGQFLNLFSF TEDSRCKKCI YCGKTAKSMG DWINLGSTAD
     TRRHFFTVAK EIGIDWEKLA GALGIHCNET SVIDAENKNY YNKANQLLEK WYTQNYCLKA
     TYTLACALDH IERRDILAKL KFNSLELSDL KTAGRTDILE RLNWH
//