ID A0A369RT60_9METZ Unreviewed; 384 AA.
AC A0A369RT60;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Caspase-6 {ECO:0000313|EMBL:RDD37866.1};
GN ORFNames=TrispH2_010026 {ECO:0000313|EMBL:RDD37866.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD37866.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD37866.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD37866.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD37866.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD37866.1}.
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DR EMBL; NOWV01000210; RDD37866.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RT60; -.
DR STRING; 287889.A0A369RT60; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 131..267
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 301..383
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 384 AA; 44146 MW; 5F4F5ACCFD551BFE CRC64;
MSWEDRLSDD KMSEILGVDL RTLYGLTQQE LNQINHQLYQ KKIISKTKYY QFQGESNRYK
MINDTWEEIS KKGEEYVKIF GYLLRQAKPG LFTTAQREDR SYAGDGNCLS GPATSPQKLT
KMPCYLMNKK PHGIAVIFNQ VNYTNSKPRE GSWKDALALE KIFSKFNYAP KIWDSLSKAE
IEQKIQEYSA TGAHVNYDSF ICVFLSHGNR KLITDKNDKK DVVDCIIAKD SGEIYLQDVY
DQFSGHKCPS LVGKPKIFIT QACRGDDQGE GVPVPNPSGT LYATDNISNS DKPGNLRHPY
SDFLMAYSTV QNFQSLRDPE NGSWFIQELV RELESNYKSF DLLDMLTNVN RRLQNYVINE
ESKSYMQQPL FESSLSKKFY FSDA
//
