ID   A0A369RTA2_9METZ        Unreviewed;       757 AA.
AC   A0A369RTA2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   13-SEP-2023, entry version 16.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN   ORFNames=TrispH2_011052 {ECO:0000313|EMBL:RDD37531.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD37531.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD37531.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD37531.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD37531.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD37531.1}.
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DR   EMBL; NOWV01000235; RDD37531.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369RTA2; -.
DR   STRING; 287889.A0A369RTA2; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR   Pfam; PF19326; AMP_deaminase; 2.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843}.
SQ   SEQUENCE   757 AA;  87913 MW;  F1DEC151FAF687F3 CRC64;
     MTELNRELLF SDHSMYGQDR SSSTPDASLF EMPDDDIAQR QIHEDALQTT MLQAGIKELE
     FKNAKDEDLA SRYRSQCNRE RFLDSTKFHR IHVDEDECSH SGILLGNLEE ASSFFVKALL
     IRQKYMKISR QSFCRTTEKA LKTYVDKSLE CIDHEDVARS ICAGLPTESF EDVNPFDIEF
     LPDNGNVCKI KNGIVMVYED KDALEREKPL DLKHPDVQEF VSDRNVLLAL CSHGPIKSFA
     YRRMSFLESR FNLHVLLNET NEIAAQKRVS HRDFYNVRKV DTHVHAASCM NQKHLLRFIK
     NKMKNCPNEE VLFRNGNVMT LEKVFRSLNL TSYDLSVDKL DVHADRNTFH RFDKFNLKYN
     PIGELVTNVS LRLKSARLKM NNFATFTGES RLREIFLKTD NYVDGRYFGE LIKEVAYELE
     DSKYQMAEPR LSIYGKSKIE WDKLARWAVN NSVYSDNVRW LIQIPRLYNI YKSNNLLNNF
     QEMLDNIFTP LFEVTCNPSS HPELHRFLPQ LIGFDSVDDE SKAENHLFHE DSPLPNEWDL
     PENPPYSYYC FYMFANITAL NNLRKQRGLN CFMFRPHCGE AGSVEHLMAA FILAQNISHG
     LLLRKVPALQ YLYYLAQVGI AMSPLSNNSL FLNYHRNPLP SYHARGLIVS ISSDDPLQFH
     FTKEPLMEEY SIAAQVWKLN PCDMCELARN SVWMSGFEHN LKKHWLGENY LKEGIESNSI
     SCTNVPGIRV AYRHETLEEE LCTICDPQIK DHIPPHS
//