ID A0A369RTI8_9METZ Unreviewed; 507 AA.
AC A0A369RTI8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Rho guanine nucleotide exchange factor 3 {ECO:0000313|EMBL:RDD37860.1};
GN ORFNames=TrispH2_010557 {ECO:0000313|EMBL:RDD37860.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD37860.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD37860.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD37860.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD37860.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD37860.1}.
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DR EMBL; NOWV01000211; RDD37860.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RTI8; -.
DR STRING; 287889.A0A369RTI8; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF8; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 165..352
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 382..499
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 96..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 58069 MW; 7FB0D1E2755D397B CRC64;
MSLNQNNLSN TFNIPMTRTR SKLLQSPMVA KTAMKENFNF SFTAKTPDKS AQTTIPKYGL
KRKLSAQDLS PPTDTFSSCK RHRPLSRISS MLSPAKPVRR VSQALHRSVT PKPSRPKTMQ
RRFSTTWKYQ GPSPLPTPTK PKASKRWLDF AESNLSNQMS KIQIMRQEAI YELYSGEVEL
VQDLKTLKEA CSSMVYYNPM HTLKILKPNE LQEIFGNIHE ITPLHEDLVQ KIMELQQANG
SVNSIGTTLI VWFPKLLPYL DYCANLFTAK LALEEKRRDK QVADFLERCK QSPFSRKLDV
WDFLDKPRSR LMKYSLLLKN ITKLTSTEHP DYSYLLNATS SIENFVSKVD IKAGMAKCSF
IQSKLFYVTD DQHIPLIDES RLLLCSGIVK NKAGTKLHIF LFEKVLVLCR QATRNEVFMY
QVHRHPIPVA SLAVEDVPDE NIRTNSLRGS FKDALSGGRA GKNFIRVSNT SSKRLQYLLQ
VNDEHDKKQW LNELNQAVSR HSHAINV
//
