ID A0A369RWE0_9METZ Unreviewed; 871 AA.
AC A0A369RWE0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Metabotropic glutamate receptor 3 {ECO:0000313|EMBL:RDD38759.1};
GN ORFNames=TrispH2_008575 {ECO:0000313|EMBL:RDD38759.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD38759.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD38759.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD38759.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD38759.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD38759.1}.
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DR EMBL; NOWV01000162; RDD38759.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RWE0; -.
DR STRING; 287889.A0A369RWE0; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd13953; 7tm_classC_mGluR-like; 1.
DR CDD; cd06350; PBP1_GPCR_family_C-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF162; G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RDD38759.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 596..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..860
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 871 AA; 97731 MW; 3AD05258B645DA00 CRC64;
MKFNLVQYPI YGQLIFLLVQ IWPGMSSKDD LSNSMLFPNK TYQPGDVILG GLFDIHDLYD
PDSNLCSSIN IRGIQYAEAM IYAIQSINDN PNLLPKIKLG YHLLDTCSSS QLALSYAIQY
AQPSNKNNQL CSTSSAHGRK ENSNKTLTKP IVVIGARTSE QSIAIATLFN QYNLAQVSYA
STSRILSNRV HFRTFFRTVP SDIHQAKVFL DLLTYFGWNY IATVAADDIY GQFLVNSVTA
LASQRGICIP LQRRFSTTKL TTDVKEIIHS LLDDTAIQVI ILICSEYQAI QFFKQAEKYN
LTGRTFIASD GWGDSPQLKT IRHDVIGGAL GVVLDQGLST DFQYYLQDLD LCNHHNHSKD
QDQSWLTSYW RQQLGMDHNM SFHSCQTRQT WLKNNGKTLD SLIADGKSGY VIDSVFATAH
ALHHALECDD HDCRLDLPLS QLRLKITPSL DNITFDGITD PSFQFDQEGN SQGVYTIINL
QPQQDTLNFI TIGMWNGSKP IDQELTLFLY QPIVWNSNNS SQIPISTCHG DCQPGSYRRY
RKNKSSCCWD CLPCPPNTIS NVTNAPVCYS CSWGTFANQS QCQDVQVTHL QISDPLVIAL
LTVVSFCAII TLLVWICMII YRRTPIVRAT HRLLTHILLF GVIILYIVPI LLVLPLTTTI
CSLVLLILSF SCTCILASIM VKTQLMLGLF NVRNPSAIRQ SLLYRTCGQF IIVSVLIIVI
VAIVGITLLV YPIEVGRYIS TNNLVYANCQ ATTKAPFIIL VVGLFIGNVI CISLAYRARK
LPSNFNEAKC ILVTCVVMCM TLLYLVPFYF ATSGLASIAV ISFGVTIFAI VVVLCLYSYK
IYLIIVRPEL NTRHSTRRTV SRYSFSQKTI R
//
