ID A0A369RWY7_9METZ Unreviewed; 757 AA.
AC A0A369RWY7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN ORFNames=TrispH2_009008 {ECO:0000313|EMBL:RDD39196.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD39196.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD39196.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD39196.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD39196.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD39196.1}.
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DR EMBL; NOWV01000144; RDD39196.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RWY7; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF76; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 268..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 325..343
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 396..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 436..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 481..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 603..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 659..682
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 694..712
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 50..257
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 260..729
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 757 AA; 87629 MW; 316ECFA4F9115F29 CRC64;
MPKKSTENID IEKLYDKSSY GKGKLPPPQV QVATATEFHD EIASYSLEEP TERPIDYVLV
YKDCDDPSNP REVERAEQRK IFEERLQEDG LQVTYEKVLH LNFVKIYCPF KRMGKEAEKV
NYEMDLAGLQ INEEPKGCIG RLFRTDEQVD YVSAPFVWNK RQAFEGVEKS RSFFRNSVRS
LLVHNILINT DIRQGADTED KINCRGLLYL IMQKAYSDAF VLHNPFVNGK KVASKIGNTE
REELYRSWGS CFQFQPLWRI RNYFGEKIAL YFAWLGLLIS SLFIPMLFGA GCMIYGLYFS
YIAQYKNGTN LDYTWLSKAC DNEVTPYYGL VVCIWGTIFV EMWKRKCATL AYKWDVNNYE
LQEPNRPEFY GTKLAKDPVT GVETPIYPIS KRIMKLLASG VCLLFMVFLV IASVTAVIAF
RVILKINSQL NFQYSNWFFS ITSSLLNTIS IMILGRIYSK IAKWLNDWEN YRTQTEYDDS
LILKTFAFQF VNSYTSLFYI AFFRKDIQRA GLFNLGTQYR DSCGTDDDCM SLLTIQVAVL
LIVKPMPKFF RDIILPWLKQ IFINKCTKKG SDIHPEVEEN ALAKEYYLYK TEDFTMSEYT
EKILMYGYLM LFATAFPLAP LLAILIMSVD MRIDCRRLLH YDRRLLANRA QHIGMWMPIL
NFLNIAGVVS NAFLIAFTSS FATYINIQTA SDRALWIVVA FEHGVFALKY FLASVIPDVP
YSERYQVERI MASTSAINDD EIPVPNVMPQ GNNNDVV
//
