ID A0A369RX76_9METZ Unreviewed; 587 AA.
AC A0A369RX76;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:RDD38891.1};
GN ORFNames=TrispH2_009085 {ECO:0000313|EMBL:RDD38891.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD38891.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD38891.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD38891.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD38891.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD38891.1}.
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DR EMBL; NOWV01000156; RDD38891.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RX76; -.
DR STRING; 287889.A0A369RX76; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:RDD38891.1};
KW Protease {ECO:0000313|EMBL:RDD38891.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 116..345
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 441..571
FT /note="APAF-1 helical"
FT /evidence="ECO:0000259|Pfam:PF17908"
SQ SEQUENCE 587 AA; 68669 MW; 0A728721F5E9B427 CRC64;
MITDIPLQQF LIDLRARQVL SNEEVDELNS FRTNKEMIYN FIKILKFRAD QDFFHLCDTL
QEHGAITVQE FGEALQNEAE LRRRAEDENE KGKPTNSAYL LRDLPPTPES HYIIRQTFVD
KICSHLKDID NSQGHLLIHG MAGCGKTIAV CQSVRMVFEQ GYFQSHGVYW AKLGDIGKDK
LFTILKSLCI KIGVTWKEPP QNLEEIDAYA KQYFEENQDK NNILFIFDDI WQKSHYNYLR
FASKSIATSR FLHPENKLHY KCISASDRFT YEEAIKVLAK NRNIQDLQSL YNNRNIALAI
ESCGGLPLAI ALIGGLHLQT DKQWESVIKV IEKKEIGDLP ANYDFNLFGT FSLSIKELEG
KKKQCFLLLG VFKKVKIPIG SIMSLWKQNE CSTISLLQEF RNKSLLRFIE TNGYCILHDL
MVDYLQQSHD PQLSNKVYWE NMNQTLVQHY FYHCQGQWGT YPNDGYFYQN LVYHAIQAHA
DVLLRTLMAD FNWMTSKFKI FKTLFNLQLD LEDYIKYLDK QKENSLQYQE LLTSLRQYES
YADMETMDFI QFLLNTNESK SWIISRALQL ACENTIRGIS RYWMITT
//
