ID A0A369RXM6_9METZ Unreviewed; 533 AA.
AC A0A369RXM6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=4-coumarate--CoA ligase 1 {ECO:0000313|EMBL:RDD39445.1};
GN ORFNames=TrispH2_008698 {ECO:0000313|EMBL:RDD39445.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD39445.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD39445.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD39445.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD39445.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD39445.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NOWV01000134; RDD39445.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RXM6; -.
DR STRING; 287889.A0A369RXM6; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05904; 4CL; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF426; BCDNA.GH02901; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:RDD39445.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 219..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..385
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 436..511
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 533 AA; 58448 MW; AAB6CB7542147D01 CRC64;
MEITSKYDCK LPDGISLIDY VFEYFDKYAD REAVVDAASG RCYTYAQIRG LARKFASALT
RRGLQKGDTV AVYSPNIPEY PIVFFGIIIA GGTITTCNPL YTPKELSHQL HLAEAKHIFT
VNLFAEKAKE AAFLSKISNI YVLGSPTGDG ITSFQELLAD DGSYLKEVKF DVREDVAVLP
FSSGTTGLPK GVMLTHYNIV SNLSQATVKG FFYVNEDDVM LALLPWFHIY GMVTILFAGL
RSGTKIVSMA RFEPKVFLET IQNYKITVAP IVPPIAVFLS KHPLVNSFDI SSLKDVISAA
APLGKDTQYA LTARLGVNVR QGYGMTELSP VVSISILGNS MAGSAGVLVP HTKAKTVDIE
TGKALPCGKS GELCFKGPQV MKGYLKNKAA TDRTIDTDGW LHTGDIGYFD KEGDFFIVDR
LKELIKYKGF QVPPAELEEL LLTHPKIADV AVIGIPDIDA GELPKAFVVK RANDVTEEEV
IAFVASEVSP HKKLRGGVEF IESIPKSASG KILRRQLKAQ EIEKYKKVNS TRF
//
