ID A0A369RZR8_9METZ Unreviewed; 972 AA.
AC A0A369RZR8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=DNA mismatch repair protein MutS {ECO:0000313|EMBL:RDD39762.1};
GN ORFNames=TrispH2_008093 {ECO:0000313|EMBL:RDD39762.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD39762.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD39762.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD39762.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD39762.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD39762.1}.
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DR EMBL; NOWV01000123; RDD39762.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369RZR8; -.
DR STRING; 287889.A0A369RZR8; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 764..780
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 972 AA; 108878 MW; A1DC6859DBBECEC2 CRC64;
MLLRCLARKT TWPSTSKNWP QFILSSQRRF NCSRYTDKIS TVSTAVKFKP TVSTMKRPHL
LKQYRDIKQS YQDFVLIFQI GEAYEVYDKD ADIVASKSTL PLLDTANNME STSALLRVRF
PKHQVDDVVK TLCREKVKIA ICNEQTTRST TSANLRERKV TKIFTPGTYT FAEYNSSIDT
SNYLLSIVDG PEETLGLSWI DVAAQDFQFT SSTLTNLSAD LGRINPSEVL ISKQMQELIN
QCEQGYLHRS LAVKIKLIAK LFQNICITSV DVADEASTRH IKRKYAQILC AMRKVKPSQL
EFEACRVLMQ YLDYIDEHLL LETLKPLKFK QDEHMLIDPT TRKSLELTTT MFGAVPTVSK
GTLVNVLDRT VTSAGRKILT ARVTAPSTNV NEIQRRLDFV SIFATNPGCA TDIHKCMQGC
HNMDVLLRTI SMNLGSIDTL RELMKILIIS DDIKDILRNR ISASDVLAVA EDLGNFIDLK
EKLIRSVMNA TDNGLFAKGY CAEADEIELL KANNDHQANN LRMQLSNQFG LPRLDLLTSR
DFHRSFCISS PAANKISNHH GYFVIDAGTS GSSKKIEFSI PELEELNTEW LQLHRRQIEL
QQKLFTDLRA KIIPLVDELT VTGQTLAELD VACALGIGAH ERGYCRPLIT EDTTFDIKNG
RHPIIDAYYS EMCVSNNCNL NEKNVWIITG PNMAGKSTFL RQNALIVIMA QMGSFVPAQS
AKIGIVDRIF ARVGACDNIA QHRSTFMVEM TESAYILSHA TPNSFVVLDE IGRGTSTLDG
ISVAQAILEY FHEVIRCRTL CATHYHQLGK LATTLKSASS YQVSAKKNSD GAIMYLYKIF
VSESRPGYCK QSLGIEVAMQ AGMPTAIVDK ASIILKKLLV TEDESFRQFS MDDLGPNSLM
ASGTKDSESQ FATLNEDSIK IIRKICKGIH PSSINPKEAI IQLYSILDNL TPKEADGFMH
TLIRLSRLAP SN
//
