ID A0A369S179_9METZ Unreviewed; 1303 AA.
AC A0A369S179;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000313|EMBL:RDD40666.1};
DE Flags: Fragment;
GN ORFNames=TrispH2_007263 {ECO:0000313|EMBL:RDD40666.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD40666.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD40666.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD40666.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD40666.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD40666.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NOWV01000094; RDD40666.1; -; Genomic_DNA.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 3.10.250.10; SRCR-like domain; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071:SF18; LCCL_LECTIN ADHESIVE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00530; SRCR; 7.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00181; EGF; 13.
DR SMART; SM00179; EGF_CA; 10.
DR SMART; SM00202; SR; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF56487; SRCR-like; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 13.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 33..69
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 78..179
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 179..216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..365
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 365..403
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 405..441
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 450..557
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 558..593
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 594..632
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 634..670
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 679..779
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 779..817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 819..855
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 874..977
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 977..1013
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1022..1125
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1125..1161
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1163..1199
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1208..1303
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 59..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 148..158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 206..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 244..253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 332..342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 369..379
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 374..391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 393..402
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 431..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 523..533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 562..572
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 583..592
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 603..620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 622..631
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 660..669
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 704..768
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 717..778
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 748..758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 783..793
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 788..805
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 807..816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 845..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 945..955
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 981..991
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1003..1012
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1093..1103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1129..1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1151..1160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1189..1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1281..1291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT NON_TER 1303
FT /evidence="ECO:0000313|EMBL:RDD40666.1"
SQ SEQUENCE 1303 AA; 139241 MW; EEE45196DE2BD401 CRC64;
MGSGFKERQK LEISSIQGVA ISVLGLSSLA SGANNTCNSN PCSSNATCIG NGFHYECSCP
VGFGGSNCNI DINSTLPIRL VNGQSYSGRV EVYRNYSWIN ICHNNFNWNA ARVVCRSLGF
TNVSTYYCCS GSFGTPQPAP SYMSNINCTG NEISLSQCLY TIANDSSCNR YSTIGIACTV
GACGSFPCAN FGTCSSTANN GYNCTCSSGW TGQQCESGIN ECASNPCSAN ATCVDQHLGY
SCRCPQGYYG NNCLNGPVSD GAIRLVNGPN VADGHVQVYH DGRWGFICHY GWDIQDARVV
CTQLGYNNAS SAGCCSQYGY SFGTYWINNL NCTGSENSIY NCSDFSWSNG TTTCSRYDKA
SVKCTVGGCS SFPCAHGTCN SNDTMGSSYS CSCHYGWMGQ QCDISVNECA SNPCVANATC
LDRHVSYACL CPEGWYGSNC DQGPVTDGTL RLVAQYNSAG PNEGNVEIYH NGTWGAICHN
SFNIKDAQVV CRQLGYTNAS YTSCCSNYGN SNYKLTWLSY LNCSGNESRV LDCPRGSRWG
DFSNGCGRYS IAGVSCTDFN QCASNPCVNG TCYDQVGAFN CSCFPGYVGT NCNIRSDCYS
NPCLNGGTCM VGSSGIGYNC SCINGYTGNE CQSDIDECSS SPCASNATCS NLIGRYECNC
APGYVGPFCY ESSNSQLPIR LVNGPTPNKG RVEVYHNNVW GSICYYGFNM KEARVACRQL
GYTNASGYSC CGTYGYTSGP VWLSNVNCNG TETSLAQCTY IGWNNTGCST YSNLAITCTV
GSCGSFPCVH GTCVSNTTMG GDYNCSCEAG WTGQNCEIEI NECISSPCSG NATCIDLFLG
YSCKCPQGYY GSNCSQDFRI VRLSSKGPVN DGDLRLYSAY NYGPDRGNVE IYHDGMWGAI
CHYSWSTNDA LVACRQLGYG NVSSSYCCSN FGNTVKRVWL SNVGCSGNES KLTDCPSSGW
NVTSSCGRSS YAGVQCIAGS CASYPCVHGT CTSNSTGGYN CSCLYGWTGQ QCQMSPVNDG
DLRLYSAYNY GPDRGNVEIY HDGMWGAICH YSWSTNDALV ACRQLGYGNV SSSYCCSNFG
STVKRVWLSN VGCSGNESKL TDCPSSGWNV TSSCGRSSYA GVQCIAGSCA SYPCVHGTCT
SNSTSGYSCI CSYGWTGQQC QMSVNECASN PCSANATCID QHTSYVCLCP DGYYGSNCQE
GPIADGSVRL VAQYNAAGPN EGNVEIYHNG TWGSICHYSF DINDAQVVCR QLGYPNASRS
YCCSYYGNQN YTLMWLSNLY CKGNESRVSD CSRGSGWGSI SNG
//
