ID A0A369S1W3_9METZ Unreviewed; 1467 AA.
AC A0A369S1W3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE SubName: Full=Spermatogenesis-associated protein 13 {ECO:0000313|EMBL:RDD40906.1};
GN ORFNames=TrispH2_006725 {ECO:0000313|EMBL:RDD40906.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD40906.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD40906.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD40906.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD40906.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD40906.1}.
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DR EMBL; NOWV01000088; RDD40906.1; -; Genomic_DNA.
DR STRING; 287889.A0A369S1W3; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45834:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L; 1.
DR PANTHER; PTHR45834; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 948..1012
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1050..1234
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1265..1367
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1467 AA; 163376 MW; 89CB22B1B9EFCDFE CRC64;
MKSTSARSGY ITRCPPQQDH HPNNLNYGRN TTPGNIVNHD EINDVNHSHY HHSPNISRYH
YDNNNTISVN PAGNSNSYNV NPNYNNHVNQ SYSNPIGINR NSSGHLYNSH HSFHQQQHLH
YGSQPSQASL SSSPSQLHYH PQQPPSSSST FSHHHHYNSY HSSQYNQQQQ QQPLSQSPSS
SHIQHLHHHH PSSSHSLHHS TPTTNRKNDL KVVEVTARPT TLNTSVSHHI VPHKNLKPIT
ITSLDDGSIE LEVSCGSDNL TLGQKGHHYH EENNNNGLTI TTTTSTSSSS ITTTTSTSTG
VRTHLSYQPT TQKVTTSVEN KNVDHPMPSS ASSPSITSII PPSPPQPQSQ PPQQSQTSSA
SSPSSSQPQL PQSQSQPSQQ SGSRRTSDSY TNNKSTSTTT NRNLHSSSSG SGNSSSSNNI
STGNNDDNGI PNCKSQDASP LPQKKVFTSS LYLIPKPMTN SGQRQYSTSS TSNSNVNSPT
TNHPPSLFPG QLQSVSPSPS LNNNNNSSPT SSNNNSVPTT PPREYPSTTI NDLEDNVAIR
RDWNPSSSTV QQQQQPNITP LHSTLGQAPY QRVNPYANGP MPSSSVQPPP TPSLSLNPMA
NNITSTNNIN SNSSNSNINA GNNATLNNNI GVSNSNGNTN YALPRCGSYH EGRRSPPRSR
SHTFNSATAN MANRTSSPDR HYTNNYSSSG ASSQGINPIY DNTGSSPLPS AGYPSSHRLS
QQQPSQQQQQ GQQLPSTSSV SSSSSLHLEL NHHHDYISPL SSPDMDVLTS YQQQQQQQTL
SLTASQPASS SSLQPLQPPQ QPSQLHREDL DHSIDSPSNS RKALLATCQL NKSTPSLLEE
FELNSNDEKT TRDDLFVEGR SQFHLGMEAS IYGSDSSLNK SSTSSVMEVH SYSIHNGRLF
NYGKKVEFDD LLKVRNDRSV RMGKVIDKMS TKRTVMAYEP TAQLLARKGP TFAEAMFDHV
SYEEDELKFL VGDIILILDA NDEDWWYGKL ITDDEDQVEG WFPSSFVRGV VSSLAVCLRV
AQETAAEEVA EKQRKTSVSS DKGVEKLAYI RGRVIDELLQ TEKDFVGYLK FIIQDVLYEA
KAHPNMFSEE QIKTIFGNLE NLFILQKDFL KDLEISVLKN DNISSRIGKC FLDYGDRFGI
YTEYCGNHPN ACAEIRRLCT NLKYQRFFEL CCKLHPLGTL GMDGFLVMPV QRICKYHLQL
AELLKHTSPT SSEYSIVKAA HQCMKGVASK INEQKRLIEN IAQIANWQKS IEAWEGDNVA
MKSIKLIYSG PVRLLSKGKV KDRMFFLFDR QLICCKKDGG GLTKGNLVYK GRYDLEEYDI
IPLETFEEEI LESEGWKVRC KDDVFIYGTA TVERKKEWGD AFIREREEVE SMEDLEIPED
IRRALIIAST KTEKKKPLST RLKLSRTNTE RILRDFNDDS EVFTRQRLNT ISGPVIDIRS
KAMQNKKAGR WTKFAFLNRK KKSEEND
//
