ID A0A369S1Y4_9METZ Unreviewed; 197 AA.
AC A0A369S1Y4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Protein lin-7 homolog {ECO:0000256|PIRNR:PIRNR038039};
GN ORFNames=TrispH2_008054 {ECO:0000313|EMBL:RDD40810.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD40810.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD40810.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD40810.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD40810.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. {ECO:0000256|PIRNR:PIRNR038039}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|PIRNR:PIRNR038039}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the lin-7 family.
CC {ECO:0000256|ARBA:ARBA00008546, ECO:0000256|PIRNR:PIRNR038039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD40810.1}.
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DR EMBL; NOWV01000091; RDD40810.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S1Y4; -.
DR STRING; 287889.A0A369S1Y4; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-UniRule.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-UniRule.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14063; PROTEIN LIN-7 HOMOLOG; 1.
DR PANTHER; PTHR14063:SF2; PROTEIN LIN-7 HOMOLOG; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 2.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038039};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038039};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|PIRNR:PIRNR038039};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038039};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR038039};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038039}.
FT DOMAIN 13..68
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 97..179
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 197 AA; 21854 MW; 79D5D9896DCE41B7 CRC64;
MATEADGKPR LTLESDINRA IQLIDALSSH RSIPSENLQK LKEVLESDFC KTVREVYESV
YDTVDINTGN EEITAQATAK ATVAAFAASE GHAHPRVVEL YKGEEGLGFN VMGGKEQNSQ
IYVSRIIPNG IADRDGRLQR GDQILSINGA SVENEYHEKA VNMLKNAQGK ISVVVKYAPK
FLEEMEQRFD KRASRRA
//
