ID A0A369S3A3_9METZ Unreviewed; 1019 AA.
AC A0A369S3A3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE SubName: Full=Huntingtin-interacting protein 1 {ECO:0000313|EMBL:RDD41002.1};
GN ORFNames=TrispH2_006887 {ECO:0000313|EMBL:RDD41002.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD41002.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD41002.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD41002.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD41002.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD41002.1}.
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DR EMBL; NOWV01000086; RDD41002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S3A3; -.
DR STRING; 287889.A0A369S3A3; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 1..129
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 739..982
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 284..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 497..549
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 988..1002
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 115163 MW; EB34492D80E1603C CRC64;
MVDSNYRNIP LKQTSKRRNI SRRLSARSMD LSRLNMFDIS SSILQNMSTV QYLTSKMKII
CWKGLCIIHK IFIEGHPNVI IESYNYKNLL SSLLSTWTAR SESYPKLIIL YLKYLDEKLE
FHKKYQAIPS NFTSQSSGSI IDLPTKDMND TYQLVVDLLD LQDQLLRLQY YVYEAVGLSG
SMNPSGQCKV FCFITIIHES YNIYGLIVKA MFELHKYLDP EFLAGHRTRF SKQLAVLRTF
YNNAHTLTYL RTLTPIPTLP ENEIEFVQGD VSNVVITSYR ESRSDFSHDS LPSPDASPSP
DLISDLDATD RSSASLSSPI SPAATIEHSF ADIPETVDMQ NVSSPRVDDS KDELINHLRQ
RIEELQIELV KCKSEFESEK SRMHEQILEY EEEIQQLKTT IKAIQQELAE YRAIAEESCQ
ENVQLKAHLD TLAIASPQVA GGEWEAKFNK MKQMYLKVRD DHVNLLRKHG NIESQLKAAL
LENGDILVEL ESKTADNDNL SQELSALVVK LDLLNKQHEQ ELRQKNNKLQ DQTKQLESVH
AEMEALKAST ETITVKASAL TDAVDERLLQ SSNEENVPTS DSDKNEFQFS MIDWSLQQAI
AMISLSLDGK NPSALPVDES LDSMLFLAEN SSQRATMLTV DLREYFKNNS DIESIDTSLR
HFISVFALMI YTSKISFHGD ENQKTNEIIE KCENAGYSVR KFLEDLRSTI KDDPSMLEAV
SEDIKHTLDA IIDLVKKQCE SANAVEKGDI VGEEMAYTTE AIDVATAKIE ALLRRARENE
TGTKLEVNER ILDSSTKLMN AIRLLIIRAS ILQKEIVRIK KGISSGKKDF YKRNNRWTEG
LLSAAKAVGA SASNFVEVAN EMMEDTCGLE ELVVASREIS SSTVQLVTAS RVKSNPRSEN
LLQLESASKL VTASTTEVIA AANAGRKILA EDDQNYDFSK ISLTQAKRLE MESQVRLLRL
ESNVTKERGY LGRIRKHHYH LAGASEGWEV DEAEEANEAS ENPDEGDKEI INKETDNPE
//
