ID A0A369S404_9METZ Unreviewed; 1439 AA.
AC A0A369S404;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:RDD41638.1};
GN ORFNames=TrispH2_006285 {ECO:0000313|EMBL:RDD41638.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD41638.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD41638.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD41638.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD41638.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD41638.1}.
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DR EMBL; NOWV01000071; RDD41638.1; -; Genomic_DNA.
DR STRING; 287889.A0A369S404; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:RDD41638.1};
KW Protease {ECO:0000313|EMBL:RDD41638.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 194..414
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 516..647
FT /note="APAF-1 helical"
FT /evidence="ECO:0000259|Pfam:PF17908"
SQ SEQUENCE 1439 AA; 166494 MW; 6A083DF2D1E1B93D CRC64;
MIIQQSHSII KQLVADERIA IDHVVREEFK DIKRKVRDWK IGEMEVLHFT GFHPSNNRST
GNAPRLSRIR CSPAISKLMK ANELKICQNI PVSVMRQKLV EYSVIEEDNL QHTNEDDDNS
NEIAKLIWKK LRDGGDRGFY IFCNILKEQS DEQLRLLGLQ LSNDAKKITA LSDDDLLRNV
PPLPQIHFIV RNDFVNQTAN AIMKIHARGG RLLVYGPSGT GKTVAVSNCL QYVIRQKQQF
LPHGVYWITI GKVDKQKLFE ILSNLMIKLE MRPQTFPSLK QLNQAISNHL EALSDLSFTL
FIFDEVEEPS YMDYLTFAKN SVVISTQSSQ AVIEKFDYNI QSQESFTQQE ALQIIGSFQE
NAKTQSWVND DIVKQVVGKY RSSPQAIALV GGAQLKSLDE WKEVQALPEA KRTTKQSENT
FTLFTHIMNK LPERTRKLFT LLGACFRVKI SVAVITILWN LPADQVSVIL QDLHQRSLLS
YASENDCRPY CQINNLIMDY LQLPSNVQYV QSDYMKNLHL NLINQYQLHC DENWILKEDD
GYFYRYFMNH LMAAEKDDII QQILSNSEWI NNQLKLLKQP SFLYANMEQI QDYLQRKDLD
STSKPLEFLK RFEKFLPKSD PDLLQLILDF APSDSPLRQQ AYKSARRLSK EGKGIYLKLS
YSENRSPENF YDIQNLPEEE EPNLRNLVIE RGNPYTLFEG KIYRYAESFD HKMKARGYGP
FHGMNMYRFS WEIVSVEEGL QLLFILENGE KATHLEACSV QFFERSNTSF VTISEEKHQL
HLWEIKDGLI HCIRSSTPTE FYINNFSFVP DTTNILVAIE RYQRWNMYMP KDLINECYIE
VWTLKNLQPI SKITVPARMN SSYKPLTGKP DPSDHLISYV GPFDDSRYLI SYGNISGLLT
IENCRDKTEK DFANHWSDMF KIIDNGYTHL AISKDKKYIA CMSYFGDILF YQVGPNEITY
YSMIVCENGN SRISFVDDSY DIMIHFDNTR LYYAFPTTYK PISTQGQANA GRNYNLQVSK
NKIVNNVLVI AEIIKTEDNF QLKVHRGDRQ EEVSSHHFGS HYKSTFVSKD HSTVDLFLFE
DLPSILLTEV YACENEDCLK DQNKRHYHCF YSLRRFDDLD HDFWVYEILV SDFKHQESQP
PSVGGISPSF TIPTLALVPG MGKYGFIDNT KPNIRIESFY RQYDNQIMVI ITESRRLIIL
FIDAASGATT AKHVEEINDI APAIAYLANE NFVLYHESNT KVCAEQERIL KKYKMQGSNI
QVVQCVKGKL FNEEERPVST YCKMTISEDN KDIQLTDVLN VDDDDKIKEQ FGLTDWKISK
KEGYNRALGI LIRKGNYVMV FREPSQGSHQ QASFYAGNRK IEFNPTSTYL PHLWDKKYAV
IAEGSGIEIY DNATLQLKLR YSPIRLCDEY VTSVQASPDG RTITCTQPHS CLNIMKAII
//
