ID A0A369S434_9METZ Unreviewed; 617 AA.
AC A0A369S434;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Xaa-Pro aminopeptidase 1 {ECO:0000313|EMBL:RDD41668.1};
GN ORFNames=TrispH2_006197 {ECO:0000313|EMBL:RDD41668.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD41668.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD41668.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD41668.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD41668.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD41668.1}.
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DR EMBL; NOWV01000070; RDD41668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S434; -.
DR STRING; 287889.A0A369S434; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:RDD41668.1};
KW Hydrolase {ECO:0000313|EMBL:RDD41668.1};
KW Protease {ECO:0000313|EMBL:RDD41668.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 45..146
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 323..540
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 552..615
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 617 AA; 69843 MW; FF3BE4A061A2AA09 CRC64;
MNNTKNGQLL RTLRSFMANM KHVPHPLQAY IIPTNDAHQS EYLANRDKRR EFISGFTGSF
GNAIVTRDKA ALWTDGRYYL QATEQLDDNW TLMKQGLADT LSMEDWLIQI LPKESYVGVD
PFLFTHELWK SYSQKLSDAG LSLVAVQDNL VDLVWTSYDR SEVPLSPLMI LPLKYSGKSV
GDKLKDIRDK MSTANCDALV ISALDEVAWL LNMRGADIEY NPVFFAYAIV TANCLYVFTS
LERITSEIFN HLKLETESEL KFEPYENVLE VIEDISSSNH GQIWISPLSS HALVNVVPKE
KRYLKPSPIA LMKALKNTTE LDGLRNAHIR DAAALCEFYA WLEKEIKINP VTEIGAADVL
EDFRKQQDDY ISLSFPTISS SGEHGAIIHY WWDPTEASNR EITETDLYLC DSGAQFRDGT
TDVTRTIHLG NPTEHEKECF TRVLKGHINL CKAIFPNGTN GHVLDMLARK PLWDVGLDYR
HGTGHGVGAF LMVHEGPHGI GSRPRKYDVP LMADMTVTDE PGYYEDGSFG IRIENVVIVK
SVETKHNFGG IGFLTFEPIT LVPIQKKLLS PELLTEEEVA WINDYHQLCR EKVGDLLIQR
GRLDALKWLQ KETEVIG
//
