ID A0A369S5U2_9METZ Unreviewed; 795 AA.
AC A0A369S5U2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|EMBL:RDD42286.1};
GN ORFNames=TrispH2_005882 {ECO:0000313|EMBL:RDD42286.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42286.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD42286.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD42286.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42286.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD42286.1}.
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DR EMBL; NOWV01000057; RDD42286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S5U2; -.
DR STRING; 287889.A0A369S5U2; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RDD42286.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..795
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016819361"
FT TRANSMEM 460..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 465..719
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT COILED 767..794
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 795 AA; 89593 MW; F1B5FD3DB3491533 CRC64;
MKLARYISSI TLVFLLKISI LQSNSLASAV KKPLYIGVMV PFSTRGPSGI DLIETVKLAL
SDINSNDTIL SQYELKAEIG FSKFNPASAI DVFIRMIMQK TIKVGIIGAQ NSRSSEYVAS
AAKSWNLAQI SHGSTSPILS NREQFPYFFR TALSDISYNL ARVAFSLHYG WTKVAVLYQI
ATAYTAAAND LVSDFKSKNI TDVYAEGVLD QFAVVIGNLK AKDMRIIYAI GQAPVILHVL
CEAYKQKLYG PKYVWILVGW YPNDWWEVEM QPHTKCTPDQ IYQVIQNYFY VYRSYPQTST
EPTISGRSPL NFNQQFQHLN NVTTTNTLRA YMYDAVWTMA HALDKTEQQL QPQNRSLSQF
NYESSDIRST IVKNIADMSI LGITGEIKFF GADRLGDVYI FQFQGEKSQN KTVPVGLYKA
ATDSVTIFSE NKVVWPNGFP PLSQSVIKIQ TLHISLGLTI IYLALSILGI LASLLFFAFS
LYYQNHKQIK LLSPRMNALF AIGCCICYVS VVMMAVDTNF TTTIGFSILC QANIWLLCLG
FTLAFGSLFA KMWRVYRIFA LKTAKRIIVK DWHLLAVVSQ LAIVDIVLLT IWTVVDPLTA
GVITSTTTEP KHDIVFKLTS YVCTCKNTAV WLGLVCSYKF LVLIFGTFLA YETRKVTISM
LNDSKFIGFS IYNITVFCVI GALTAFLIGP QPTIKFALLG GFIIFCTTIT MFMVFLPKIN
LWRNPNRWGR RKIADQQETF VDESLRGVGL VSSDTTFTTI ESGRCALQNA YKKYHKMEEE
IKIIKNRIEE MESQA
//
