ID A0A369S6Y2_9METZ Unreviewed; 1398 AA.
AC A0A369S6Y2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:RDD42509.1};
GN ORFNames=TrispH2_005569 {ECO:0000313|EMBL:RDD42509.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42509.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD42509.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD42509.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42509.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD42509.1}.
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DR EMBL; NOWV01000053; RDD42509.1; -; Genomic_DNA.
DR STRING; 287889.A0A369S6Y2; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50209; CARD; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:RDD42509.1};
KW Protease {ECO:0000313|EMBL:RDD42509.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 3..93
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
SQ SEQUENCE 1398 AA; 163523 MW; 6C0EC3AC9D9048E8 CRC64;
MVLSQYITDV INKNRRIISN DVPLLDLIYD LNSEMIISDD ELVKLRDKCD NNKQRAFEFI
QLLKSRNDEN FFQFCSILKE AQVQHVQNIG QKLENEAKAT KICDDGEEHA IQDENLLRNL
PIIPESDYIT RNEFVNTICS ELKRIHENSG HILVHGMAGS GKSVAVCQSV RRSIEADNYF
KPHGCYWIKI GNISDEKLLS ILKNLSIRLG IVWVQSPQTL DEISAKIDRF LQDNSEIART
LFIFDDIWNE RHYDYVAFAK KSVATSRFNY ARNKISHILI STREQFTDDE AMALIAKRRE
YDCHQTFLNS DTVKNVIKSC AALPLAISII AGLDLQSDEE WEEIRKRICS KDLMNDLPDY
ELNVFNTLDL SVSKLNDSEK SLFRLLGVFR AVEIPLASVI CLWKIEITKG IELLKMLNRR
SLLKYSGGKR RYVVLHDLMI QYLQQSTISN LSRQEYHKSL NKELIDGYFA GCGGNWSSYK
DDGYFYQYLI YHVIQAEADD ILHQVMTDFN WMMIKIRTDD TIYNLSQDVN NYIDYLRKRN
KDWHEFNQLL DLLKQHEFSI DKYDMDVIQT LLWYGERDSM MRERAVQLAR INTQADDSVY
WIMFLISGNT VTEYTYNASK RFGKNFRDDS ISISNPNSGN SRIVGTENNG TTDCQIIVKD
HQTSHIVYQM SPSYRYISSV EISADGCIIA FRYRDDKIGM SAHKWKVYNI NSNKQLPFIE
NDEELQNLDF SSIQFCPNMK NNSVMITVSS NRCLVKLWRI TDDREIKSEN KLVSYNYKIE
SCLWIKCGSQ ILLWWRRYNF DKHHDNYKPL DVNNWINECN IEVWSLKAWH LLRSVTVPAY
IGRTCNQYTA TTNIEGGQPL VCVNSISNDA ALMILAYKNI VGLVNLERKD HDPEICRKGF
AKNFRLTLDL SHSSSVANIT VSDDQQFVAI NCVKSSDENI YLMTIRNNQI RSYMKINMAH
AKSLTFMPDT AVLFVYESSS ENCLYEYNLQ DDNLRWQNFQ NNKAIQDYLT QEESQRVETQ
ILDVNYAYIN GVPFVAQLIE NDTTCKLEIR EYEAKLCVRK FYHSLENGYY RCFLYNDFRS
AVVVRFYRQN LGLNMVIAEI IDFCSEKDRT EIKKLLDHNI SLRGRIFDLK TRYRGRDNTL
IFVVSTKGDG GGLGMIIITI NLETEEKMIY QEESRYRSMD LLYYDDDYLV TCQTERKERM
KDELDHEHSI KCYKFGDGKS QTQLLERCSF DSQHGLIYKL TLPTNLSHYK LDIKYSSLNL
DTGKLLEEWG EKDGNLLMTH AGSLWKYQYI CLLEKGEHLA ILNGWGRVIM KRYKNNIIKF
DFDTSIFNCE NLWSDKFLIV LEDNSLHIHI YEAQTLQLCR VLPLSHLDMW YMKWNCQQSS
FIVSNMNRDR YAIIDRVE
//
