ID   A0A369S7A8_9METZ        Unreviewed;      1629 AA.
AC   A0A369S7A8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN   ORFNames=TrispH2_004810 {ECO:0000313|EMBL:RDD42787.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42787.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD42787.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD42787.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42787.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD42787.1}.
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DR   EMBL; NOWV01000048; RDD42787.1; -; Genomic_DNA.
DR   STRING; 287889.A0A369S7A8; -.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 4.
DR   SMART; SM00028; TPR; 12.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   REPEAT          127..160
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          295..328
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          379..412
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          421..454
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          1258..1449
FT                   /note="C-terminal of Roc (COR)"
FT                   /evidence="ECO:0000259|Pfam:PF16095"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          751..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          926..956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1629 AA;  188046 MW;  A1AC5581A5539F2C CRC64;
     MENQEGGNLL RSHDSSNEEN QPKVKAIRSG GMKVNVFLTR EIQSKRQMGR YYFQQGEYQS
     ALINYKAILD KMVDPVDITI EQDCYQCDIL LDISDTLREQ YHYDDAQEYC IQAEKIAKKV
     KDKLRLAKCY DNHGKLNTIR NHYQQALEDF NQALEFKLSL LDDRNLHVSD TYHSIATVLY
     LVDENSQALV MYQKSLNIRL NLLGDENLYV AYSYHGIANI YRKQHQYDDA LTMYQKSLLI
     QLAILGYNHV SLVGIYNAIA TLHCSPSKCN NAVKIYQKSL DMKLEIFNKY HLDIADTYHG
     IGNVNYLQSR YDDALKLYQM ALDIRLKLVG NCNLYIAQSY YAMGNIYYYQ DKIEEAQEMH
     EKSFNVRLAL LSDNHLLVAQ SYYMLGQIYL SLANYSDALS YHQKCLNIRL KVLDDENLLV
     AHSYHAIASI YHKQSDYDTA LTMYKKSVQI KLQLFGNNYD VAYTYDSISS LYLDQGQHYD
     ALSWCQKSLT IGLTLFGENN PFIANLYDKI ATICERQEKF SEAATAHQIS SSIQTKINFK
     NNLTSSSYIW KPTLETQDDN NDIPLEKFNR ILNEDQADGN IDSSDLEYSW AIPSTPKTPI
     KEISIDEFID LYQKNGNSSK RDKVMMDALS DSIEEKEVQE TNDKNNNSTR SRSDSRVLLK
     VTEESIEKMI EELSDPEDAQ EKVLSITGGM LYKSDYDDEN VRQCQFGART ILDFTEDLNE
     GTIQNWRDIG GSIDCFQDSL RTTLKTIIES SEGEDNDLSD ESKSVDHQEE MKVTPSQLEA
     LIEENIIAKL EGNRLTYLEM QEQSVNVDTE NHANGKKEGV TEDNFLSNLF KIVIDSKRRN
     DFVRLMFIGL SNAGKSSVIR ILTQNGIIEN LQSTKIINTN NEVVNLIHDD SSTNPWICDF
     IKVLNQKLAT SIDSVKRELI ENLPAAHDGN GVDAKNNNNS SITDDHGENK HLSGTEKKAE
     IVKDPYLVID REKKEVIQMV VDHQQEDQIE TRHVAHNSTN LLVNSSSEET TLSTHISNQY
     QALGKLAVNK YFRSILEALE ATVQVNHDRY GSLWEFCGQT MYRCLHYPFI PGRGIYILVL
     NVTSDLSNTQ DDQSANIADL EGLHEWLTLI IGSSDNREQI KMTVDGIDEE YSWPVIVLVA
     SYIDSAREQY QLEQRFKQVE RQLISSLPPL YRCHIYSSGI LFNCNPNDNS QATVSQRLQS
     SRNLLHIVGK ITDILPFMND LIPIRWYMMT ILLQPKPFTN KENNTMFPNQ MKQNISNPLS
     NIMTMQQMQQ FAIDHGLYKD DPDLHDMLMY LHDFGKILYC YHKVDDRIIV TNINWLLNIL
     YTISALEEHQ FHSAAIRHDY QVARTTGKMS ELCLNYAIKR FHLGSNEKEI ILRLMAYYHI
     ACQIKSNRID HQNEERQFFV PYILQTNTNE LELTGYHRSN WLYIGFDRND MNCIPDAIFY
     CLLVSCLNQW NNPQIKVFNQ CAQYSLQDED YEIIVRKERS YIGLQYCYQI IEDKDLADLV
     LNNIKLSISD KRPHDMIREQ LSEIVAKRMS KFKKASCQYY VKCPKCLLPT CTARCYQNNP
     CVIRCQCNQV FKSKSVEEWM MGKSIDLCME KDLNSKEGPT ESLSSIPVKT AEKLRRSVSI
     RARRYCDVQ
//