ID A0A369S7I5_9METZ Unreviewed; 2133 AA.
AC A0A369S7I5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE SubName: Full=Myotubularin-related protein 5 {ECO:0000313|EMBL:RDD42865.1};
GN ORFNames=TrispH2_005226 {ECO:0000313|EMBL:RDD42865.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42865.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD42865.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD42865.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42865.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD42865.1}.
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DR EMBL; NOWV01000047; RDD42865.1; -; Genomic_DNA.
DR STRING; 287889.A0A369S7I5; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20828; C1_MTMR-like; 1.
DR CDD; cd14534; PTP-MTMR5-like; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF109; SET DOMAIN BINDING FACTOR, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..461
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1298..1812
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1950..2000
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 2025..2131
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 89..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2133 AA; 239740 MW; 8914184740288648 CRC64;
MPLLAALEGK TQLIGKVLQR FPEQDRRDAA FPSGIEMFCL PTGWKCINDA VPPDPTFYVV
TLTNMEGDRF YCASLAFYEL RDTITTKTHE HHPSISEGVE RQSVSSQPSS TDLSKPSSSE
MDIRGSIILD TASLSETIGN IYLPKAICIV SRLALFESFR HCLCTLYYAV YNGQTYLLEE
LVPRILSDMY LPPAGYDKVA FKLDEGNFIT LQAAREESLP ITGSAISSFF KHFGIQNSLT
LFCAILTESR ILFTSSSFST LSLICHGLLA LIFPVQFSHV FIPILPTNLL DILDSPTPFV
IGVSSSCREK LDRMNESSEV LEEIVLANID GGNVIVPERI QLPPLPRIFH DKVSRALNAV
VNTHLVTADL AFQPVDVKPS PPTVQDKELR AIFLRLFAEI FSGYRTCLTL TRILSKPIIF
FDQEKFLQQR GLKGEPFMEK FLDSMAFHNF VSSNGIPYRE CNLFDELLAN IDTIIENEGD
DHVKFMENVH NLAAKLQDNE PVISHTPKFT DQSLQQCNGG IENTNLGNFN GTMQTFPLLT
SETVESAIAI SKTVIPQRPN KATIVPGSMG VHTGRKGMKL TGALMLKRLE VLRKCVSNIF
NNRIIEAKKM FSAVLSLLTS VQYRIALVEE FESYCLHSRV VLTFDQFDMV VRLINQVLQE
DDANDRNGVA AMILPFSASF CRKLSDNVHQ FAYTCVWDHP VWDNPRFWER TFYLTCQKHV
MNLYENSLIK KANKNAIEAK NDNKVEDVTA VETVETAINT DTENGKPKAE TTFGTTLVPS
TSTSSINGAD SRTDISSPKL TNSNTNLLNA PNTPSVTSLI SSTTGSSNDE YHPEIEDLDP
NVPVIIGETM AGKMPMDIAA EQLKKWEAYD NTEKEKLTGQ EQSTIYTQAI NYVYRLIFLR
LTMDLVSVPT TNSRSARNLK ADAAQASLYS FTANEGQDDD GLVGTAKLLL KDLSHFIDRV
CVESGLSSDH IRTVQTLIPS ERIIEDPVFA KWENKLLNVT NNSKHFLDLG TIKNHLEELR
LVKAETEKLP QRRKVKIVEP PLLPNESIIT PASEGTTYLR AYLLPDGREP GLGGLPGTFG
PNLFPAEGAV FLTSYRIVFK GFPLDPTVSE MHVCRSFPIG SLTKEKKLPA TFLEVINAHL
TECLQLRSST FELMKLAFDD EVGSERVEAF KKQLLKLRSP HSVLSTFAYE GAPIIEEKVI
YMPSNEATAP HVSQKLKDKT SAFKDITTNR MRHALHHGVK FLGRRSGNTG SINNDSEGSS
IGKKVAVVST AAMAMVGGEE RSSSAHSMIE DATDNLPAHT YKRPIEELVK LPYVSDYERL
HLGSLVKFNL KSPGHWRMTT INEDYSICKS YPAVVVVPHG FKDESIALLA KNHKQNRFPV
VTWIHPQTKA VLLRSGTINR ASLSSLFKLT TSGGSEGNAG VSSGTTADNE AEEEKYLTAI
ITGTPRIPKL KTGKSPNPAK RRNSSSSPRN SRNARIGRTA SRKVTQIQSQ TIKRLTTPNS
SPHRDPVSEN NDGYLNNTMY ADSLIDKRLA GKDWEAAHLY VLGDKSAIKQ VKNEQNSKCE
FIPVEYPESR SVRSSFKKLL RCCCPSNAEN GQSFYKAVEE SEWLNQVQCL MQVSGAIVDL
IDIQGSSVLL ALEDGWDATS QIISLSQLCM DPTYRTLDGF RTLIEKDWLA FGHQFSTRNC
MLGSTQSTNF TPVFLQFLDA VHQIMLQYPQ SFEFNLFFLE TIAYHCCSSR FVTFMFDCER
DRHYLEKSVL ANESESFEKC LSPLKNTIWN YIDDVHRNST QFYNFNYSVH KMTQILRPVA
SLTNLKVWDY YIKRNLYIGS PYDIELLIVA KQLEDDQIAS ERSNLSKRSA DSCRVISGCF
GSLTHLMRSR RALLFDDYLK LRSVSNTSID PWGKLWTTIL HSIPKESEYV KYRAIQEAKA
YSFLLHKRTS GEIILKGKMI GSAATSFTHP HNFEVHNFLA PLYCDYCMQI LWGLVKQGMK
CSDCGYNCHE KCAPLVPWQC SKIKGLKLEG PSPMDNTIAD SKTDGKWLEN TLHKRGTGNL
FKAWKPRWFV LDFDRMQLRY YENNVDQNCK GLINIAEVQK VTKSNNMQGA PKKQDEDCFF
EIITERRVFH LMADDREIAK KWLDGIQECI DNQ
//
