ID A0A369S8L2_9METZ Unreviewed; 704 AA.
AC A0A369S8L2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Transducin-like enhancer protein 1 {ECO:0000313|EMBL:RDD42794.1};
GN ORFNames=TrispH2_004819 {ECO:0000313|EMBL:RDD42794.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42794.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD42794.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD42794.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42794.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD42794.1}.
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DR EMBL; NOWV01000048; RDD42794.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S8L2; -.
DR STRING; 287889.A0A369S8L2; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814:SF21; TRANSCRIPTION FACTOR UNC-37; 1.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 16..115
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 503..544
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 545..586
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 109..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 24..58
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 123..140
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 77390 MW; B3752E389ED8E3A0 CRC64;
MFPNRHPAPH QPIGQFKFTT PESCDRIKEE YQILQAQNQS LKLECEKLAN EKTDLHRHYI
MSEVAKRLSG ICAQIIPYLS QEHQQQVANA IERAKQVTVT DLNSIMGQQQ VHLQQHHPHG
PQIPLHPGAP PPPPIPPVSA GNNMIMPSNL LMSHMALKDK EIPGGEPVRN SASPSLSAQR
PDKHRTTDAA STSSNSSIHN HRSTGKRKQD DKIDSESDKS DGELVVDVAN DEPPSPVRDT
VRSPNISLIP KEKMMKKRND MSPISSASPS PPPMKSKIID KQKPLQVGSP VPPTNNNATG
SGSTSPSLSK GHSIMPQGRT SMSMTGPSYF VQPHTINSEI GTTSYVSNPA MMQGGMPQYG
QHMVPFDHNP PGRFGVSNKP AYSFRVGADG IAQPAQFPQD ALMDSEIPRH VRLMDSLNHG
EVVCAVTISD RSKHVFTGGK GCVKVWDINQ LNKTVSVLEC LPDNYIRSCK LLPDGRSLIV
GGEASTLIVY DLTAPVPRVK GELDANAQAC YALAISADGK QCYSCCSDGH IAVWDLHNQH
LINKFQGHTD GASCIDISRD GLKVWTGGLD NTVRSWDIRE GKEMDKYDFK SQIFSLGCCP
SDDWLAVGME SNHVEVIQMN NSEKYQLHLH ESCVLSLKFA HCGKWFISTG KDNLLNAWRT
PYGASIFQNK ESSSVLSCDI SRDDKYIVTG SGDKKATLYE VMYN
//
