ID   A0A369S8N6_9METZ        Unreviewed;       338 AA.
AC   A0A369S8N6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE            EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
DE   AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|ARBA:ARBA00031085};
GN   ORFNames=TrispH2_004910 {ECO:0000313|EMBL:RDD42921.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD42921.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD42921.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD42921.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD42921.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00001937};
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC       de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004912}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily.
CC       {ECO:0000256|ARBA:ARBA00009263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD42921.1}.
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DR   EMBL; NOWV01000046; RDD42921.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369S8N6; -.
DR   STRING; 287889.A0A369S8N6; -.
DR   UniPathway; UPA00128; UER00190.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR   CDD; cd05260; GDP_MD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR   PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT   DOMAIN          14..324
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   338 AA;  38072 MW;  6FAFDC142092E385 CRC64;
     MASQTSESRP KIALITGITG QDGSYLAELL VNKGYEVHGI IRQSSSITTG RISHLYEDPK
     THTAKAIKLH YGDLTNSNCF VKIISSVQPD EIYNLAAQSH VQVSFDLSEY TADVDAIGTL
     RVIDAIRTCN FSNKIRFYQA ATSELYGKAN EIPQKEITPF YPRSPYGVAK MYAFWIVVNY
     REAYNMYCCN GIAFNHESPR RGEIFVTRKI TRAVAKIYLG LQEEAIWMIL QCDKPEDFVL
     ATGKTHSVRN FVEAAFAIVG IKIDWKGSGV DEVGVDEESG VVRVRINPKF YRPAENFLQG
     DNTKAREKLG WKPKVTFQEL VAEMVISDIE LMKKNLEV
//