ID A0A369S934_9METZ Unreviewed; 651 AA.
AC A0A369S934;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=E3 ubiquitin-protein ligase RFWD2 {ECO:0000313|EMBL:RDD43416.1};
GN ORFNames=TrispH2_003979 {ECO:0000313|EMBL:RDD43416.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD43416.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD43416.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD43416.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD43416.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD43416.1}.
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DR EMBL; NOWV01000039; RDD43416.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S934; -.
DR STRING; 287889.A0A369S934; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR CDD; cd16504; RING-HC_COP1; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR042755; COP1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR44080; E3 UBIQUITIN-PROTEIN LIGASE COP1; 1.
DR PANTHER; PTHR44080:SF1; E3 UBIQUITIN-PROTEIN LIGASE COP1; 1.
DR Pfam; PF00400; WD40; 5.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 48..89
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REPEAT 433..475
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 519..559
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 145..209
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 73671 MW; 1A4CF2D025C7E64C CRC64;
MATSLGARNS NGNNGNGNSR RLNRKRPLTP IDDGISDTYN DRNNDYICPI CFGVIEEAYM
TKCGHSFWYC HYECIRRSLD ENSKCPKCNF QITDKVDPIF PNITLNELII KHKRRLDVAN
KCEASGNRLD VADILSSKSN DDMVLSDINY LLESLSEKKQ QLELNSKSNR LQLLKEFLLQ
SRKNKEEQLN DLKTKLDLLS NDLKVVEENL VQFPTASTSP AFNGNVGVAA TSNNLNSTVN
AGASTSVNIE FREETDLPLQ RQDGFNGSKY VNPKYLVSHS ISERRKRLSI HYEDLEDCYF
SIKQSGAGSK DDSLELFMEH LSKFTKFDRF RALATLNYGD LYNHSSIVSS IEFDRDCDYF
AIAGVTKKIK IFEYSSIIRD AVDIHYPVTE MTCSSKISCI SWSAYHKEVL ASSDYEGTVA
LWDAFNGVKT RCYQEHEKRC WCVDFNKVDP KLFASGSDDA KVKLWSTNLE HSIASLEAKA
NVCCVKFSPV SRYHLAFGSA DHCVHYYDLR NTSKSLADFK GHRKAVSYTN FVNENEIVSA
STDSQLKLWD LNVPYCTRTF RGHSNEKNFV GLATDGDYIA CGSENNSLYL YYKGLSKQLL
SFKFDVVRSI FDKDSRDDDS NEFVSAVCWK RGANVLVAAN SQGTIKVLEL V
//
