ID   A0A369S9M6_9METZ        Unreviewed;       751 AA.
AC   A0A369S9M6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   13-SEP-2023, entry version 14.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|EMBL:RDD43479.1};
GN   ORFNames=TrispH2_004173 {ECO:0000313|EMBL:RDD43479.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD43479.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD43479.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD43479.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD43479.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD43479.1}.
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DR   EMBL; NOWV01000038; RDD43479.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369S9M6; -.
DR   STRING; 287889.A0A369S9M6; -.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT   DOMAIN          66..200
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          237..508
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          662..751
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          551..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   751 AA;  84619 MW;  104357E0705AC834 CRC64;
     MNGTNARNDR FSSSPNLKYF GEEKESGALY DVYLKRIHYS ALAKDLKQAI DADASGVSHM
     QWHTCKVLYI KAGTVKKAVH YINPKQQEND PSFANILLCT YKTFTTPEEL LDLILMRYRQ
     LNDVDDDHND PDEDETAKEY AEATQKCLRN FIYSWIEEYP ADFDQHPDYP RLNKLIEFGR
     NVMKNEKLIE RLVECQHSFQ SSHQGTASTN EDDDAESDCS SNCGSASSLS LDFLSIPTAN
     FAEQLTLLDA ELFRKVTPHQ CLGGIWAKRN KDDGNELTGS VTATIKQFNR VLFSVVTTIL
     NYGGDSSTPH LRGKIISKWI DIAQECRILK NFSSSKAIIT GLHFSPIHRL KKSWQNVNKD
     KIEIFEDLLM LFSEENNQKL SRDVLWKEGT AKFSEVTGSG LRRLSRRRRR KSRPELPMVP
     QGTVPYLGTF LTDLTMLDTA NADMTEDKLI NFEKKRREFE VIAKVKLLQA TAKNYMIVAD
     KEFRRWLRSL DLLTEDESFC LSTDIEKDGT PKTKDRKSGV LHSVKNLFGG VNNSVDVELI
     PSESIDSLDT ESISLTPNKE TRRSSIGSLT SSSSGEGMTG TTTATTSTIK TNTQSPVIVQ
     QTKLATSPQQ TGGHMKLATS PQQSGGHPRL ASPPQQSSSL MKVATSIQQT SGPMKFLSSP
     LGCYVVKVIF ENHNYTNITK VYKSIVISSQ ERTNSVIQKV LFKYGFQDED PNSYELLQSM
     DKKEVAIPKG TNVYYALNTA QQEIYMIVRK I
//