ID A0A369S9P2_9METZ Unreviewed; 734 AA.
AC A0A369S9P2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|EMBL:RDD43194.1};
GN ORFNames=TrispH2_004426 {ECO:0000313|EMBL:RDD43194.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD43194.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD43194.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD43194.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD43194.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD43194.1}.
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DR EMBL; NOWV01000042; RDD43194.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369S9P2; -.
DR STRING; 287889.A0A369S9P2; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RDD43194.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..734
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016744139"
FT TRANSMEM 455..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 519..713
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 734 AA; 83886 MW; 6DC33C5CF52D4B15 CRC64;
MVKVIHPIFI FLCLMTGPRS FCYGQKKCLY LAGLFSVESP DWSAGGLLPA VHMAMGDINL
RDDILPNHNL CLIWAETKGQ TALGVRNFIR LLDEPPTKIA LLGSSYSTVT AVIAELSPFY
NMLQISFSSE SSFLANRKSF PLLFRTAYSY SKYGEAYVAL LNHFNWTRVA VIGRNSYTNY
QDIYRVSSAI RKSGIEVKAI ELFLAETPVF ERLKRIKDLD VRIIIVISLE KDMLGLACAA
YKLEMYGKKY VWIIPHWYEK KFWDKISQTS KCLPEHIYAV INHALSISVL YMNYEYIETI
TGMTPKEQER RYLNRPLIAN KTYSPNGYWP FAYDAVWSIA LALNNSRNQL ESLNKTFEDF
NYQQSEMRKI FYQNMESVQF LGISNNVSFD YNGDVDANIF DVRQYQGDDK VKIGTIRRRN
IILVAEMETS IKWIDQKPPP SADIIVDRIQ PLQTIILYIM IFLCSLGYAI TFLSLSFIVK
HYRTRTIALI ATDCAILFGS IILYTSVILM GLNDEQTRSV TCMLLPWLNC YGFALVAGSI
LIKSLIVYRN VTSRWFTKEI GNLHVLAGLL SLLLLESAFL ISWTSIDPLK SVRVSITSNL
EDDEIIPYVK YRPVVLLCKC QFGTYWLIGT IGLNGIVLLF SAFIAYEARD VRLNNEIDVR
NISTCIYNTI LLGLIVIPLS FVIDRKNNEL YMVIGGYVIF CTTLCQLILF LLKGRKSDDK
IRPSVVKRNT SETT
//
