ID   A0A369SBT2_9METZ        Unreviewed;       450 AA.
AC   A0A369SBT2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   13-SEP-2023, entry version 15.
DE   SubName: Full=26S proteasome non-ATPase regulatory subunit 12 {ECO:0000313|EMBL:RDD44367.1};
GN   ORFNames=TrispH2_003020 {ECO:0000313|EMBL:RDD44367.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD44367.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD44367.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD44367.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD44367.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- SIMILARITY: Belongs to the proteasome subunit p55 family.
CC       {ECO:0000256|ARBA:ARBA00006397}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD44367.1}.
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DR   EMBL; NOWV01000026; RDD44367.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369SBT2; -.
DR   STRING; 287889.A0A369SBT2; -.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040134; PSMD12/CSN4.
DR   InterPro; IPR040896; RPN5_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10855:SF1; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12; 1.
DR   PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18098; RPN5_C; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000313|EMBL:RDD44367.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT   DOMAIN          225..407
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
SQ   SEQUENCE   450 AA;  52171 MW;  0CC6F2C05744E809 CRC64;
     MMEVDITQNS NEKLQECEKL AKEGKLNEAL EILYVIEKHA RTACDAPATA RILVSIIRLC
     FQAAEWDMLN ENIVLLTKRR SQLKQAVAKM VQEAFTFVDQ TPAGAIKLKL IEVLRQVTDG
     KIYVEVERAR LTRILSEMKE KEGNIDEAAR LLQELQVETY GSMDKREKVE FILEQMRLCL
     TRKDYIRAQI ISKKISRKFF ANDEAQDLKL KFYELSISLA EADSAYIKVC QYYSEIYNTP
     IIRESENKWK EALQKMVIYG ILTPSSHDQK QMILRISQDK NLEKILKYKE LLDCFISQEI
     VLWNSITTRF QEVILKGCEE SPNTNLFETD TDDGRKRWAS LKERVVEHNI IVIASYYTSI
     KLGRLAELLH LTVAETETFI SNLVISRTIF ARIDRPAGIV NFIKICEPDL KLNEWSTKTR
     NLMGLINKTT YMINREEMLK AKGNNLILTD
//