ID A0A369SD13_9METZ Unreviewed; 869 AA.
AC A0A369SD13;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cyclic nucleotide-gated cation channel alpha-3 {ECO:0000313|EMBL:RDD44818.1};
GN ORFNames=TrispH2_002895 {ECO:0000313|EMBL:RDD44818.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD44818.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD44818.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD44818.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD44818.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD44818.1}.
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DR EMBL; NOWV01000022; RDD44818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369SD13; -.
DR STRING; 287889.A0A369SD13; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF7; CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 168..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 482..597
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 827..861
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 100260 MW; DBFEAEF190D4A4C5 CRC64;
MSKDYDIQSA HQDYPTKNGH DPHLQQQQEH IMTVEETTPI EGGSGKKRLQ RNNRSSSSHI
LSQFYRWSNA FTKVRAQNQS VQKRRHDSFI EKFTTRQDRR ISIDSEEDLV TVANEENSLS
DDKSHGKGRD DDDDVVITDQ KDYFYDTYGD VRMRYERWII NPKSLTNLYW LALLSLAVLY
NFWLIIIRTA FPEFQNETPI LWGFLDYSTD LIYIADIYLS TRTGYLSHGI VVTDRHKLRQ
HYFRSGRVVM DVICLLPFDF FYYNVTQMFP IIRIGRLLKY YRTNDFYRLI QSRTYRPNFW
RILNLIHTLF ILIQWFAAIY YMISGYIGFG SDGWVYPEPV GINGNLSVKY LKSVYWATLT
LTTIGEIPSP VTQIEYLFTL LSYFCGLFIF ASIVGLLGNV IAKRNARRSQ FDQLLDDAKE
YMSKRNVSSN LQTRVQRWFD YSWERGQLNG IGEARAISML PTKLKTELAL HVHLETLKKV
TLFQNCEREF LHDLVLKMKH HIYTPMDLVC QLGEIAREMY IISNGKLEVL SESGAVIATL
KEGDFFGEIG VLSLSEAANS FHLLTVYGFL DRRTANVRSI GFSELFVLLK DDVLEAMEDY
PKAKVYLTQY AKARLAGMKR VNSETQDTKE NCETDTNTAR NRVGLRKILN LSITRNKIKP
INKNEDQGEI QIKRSHTISG GRSGPSTSKI RRRLQSATSR KRFSNSSNNI NVDNDISLPM
REDIERNETQ NNSKYTSNFT GPVTSTTYAN LLPYASDNTG TVENITTRLA KSAKSIENMI
HDLQAEVASN HATNARGINS LYKLPTISSF YVPRTEDEKS SLTSVEVQQL KGLVRQLQDD
IEEKNKTINN LTLEIHKFQG DTTNKNIEN
//
