ID A0A369SD91_9METZ Unreviewed; 1007 AA.
AC A0A369SD91;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rab GTPase-activating protein 1 {ECO:0000313|EMBL:RDD44452.1};
GN ORFNames=TrispH2_003107 {ECO:0000313|EMBL:RDD44452.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD44452.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD44452.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD44452.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD44452.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD44452.1}.
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DR EMBL; NOWV01000026; RDD44452.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369SD91; -.
DR STRING; 287889.A0A369SD91; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219:SF9; GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 3.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 164..236
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 516..703
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 824..904
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 966..1000
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 114888 MW; 068C1A9A787B1B80 CRC64;
MADKEENGTK SDATSSENLI SVTTKEISDD QADSRAPIAD EGATSNEDPP SNQFNMNTVL
EPTFAKTATN SDGPSTTTLQ QSVTPEHLIA SNISESSEAP KASKESETQD TTYEIFEGLT
CLGSSTVNAP KSETEAQRVM ATMRENSAKA IEVNLSVPSD VKGSVALLDP ITGSEICSYP
VTRILFCARG NPKAAEKDCF SFSSTYQKTE IFYIHVFQCT NQSLAEKVLK ALGNAFRNMD
VQNSPNSDQD NPNITSFSFQ FDITLDVLEK DEGIFRPVPR ESGVFKIREN RFKQFSAILK
QISGPTNVNI IKCMGLLLCP GPAQLAKTEK LFPMNEIYFK INNGNKNYEV IGVWNPETLF
NVNSINAKTP KGMQVYATLA MDVVFDRVLE PVRLLWDIKL KVYERLEIVP ESDRMTRHSE
SFMIQVKKMP HQEGIKGNYR VTGTQRICVG LSINNTSQQN EDLNSGNSDD ETVLSGSGNV
QQDCSDNALI DWSEVLTRWT NTKSRPKELI QLVRKGIPEP LRGQVWQMLA GIVENTDLLQ
TYSHLLTKES PSEKTILVDL GRTFPAHPMF KDQDGEGQSN LYRICKMPEE QAFCVLVKIM
YTDGLRDLFR LNFEQLHIKF FQLEKLLEVY HHNLRTYLTI TFISKLTPSS IYNKKMLPDL
YYHFQGNRVE AHMYASQWFL TLFTAKFPLA VSYHVMDMFL CEGMEVLFRV AITILKHISK
ELLLLDFEGI MKHFRVTLPK KCLSEEFCSR VLLDCGRVKI DSKKLRKYEK EYYILKELRE
EEDPVMVLEE KNRYLMRSIA KTRQENESLG QELTILKTIH NQSTEEAKEN MSLMNKELTS
LQSQYADLDE DKRRLQAEIK EIKELYRDTV AKSNDEANRQ TNIVKEYKQI CSQLQDRLEK
QENVYTKQIK TIKAKILKKY PDLADKVDEE IDSLADENAI GADDKSKSYT ELGALEEKFR
KMEVDYAHTK LELVAKECKI QELEHQLSGL EVTLAKHGSN WFAKWKK
//
