ID A0A369SI83_9METZ Unreviewed; 761 AA.
AC A0A369SI83;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Glutamate receptor ionotropic, kainate 2 {ECO:0000313|EMBL:RDD46625.1};
GN ORFNames=TrispH2_001054 {ECO:0000313|EMBL:RDD46625.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD46625.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD46625.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD46625.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD46625.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD46625.1}.
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DR EMBL; NOWV01000007; RDD46625.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369SI83; -.
DR STRING; 287889.A0A369SI83; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 4.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:RDD46625.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 423..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..681
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 304..369
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 761 AA; 85193 MW; 4180200136A17E3E CRC64;
MRDRIWAIIG PMASTDVEAV QITARALSIP HISPVATYIG LSNRPSFHYL LRSSPSDHWQ
SLALAGVFEH FTWQYAAIIL SNTDYGARVI VLSCSPLEAK VIITRAHYIE LLPNKYQWIL
FNDVFASGTI GNNPPKYLDG VLGISNSHNQ GPLYYPVVTA WKNKYNKELQ PGFLRYYDAV
MAIVYGIDNI TDQLDSIQPT NTACSPITPW RNGKIVMNSI AKATGPGVVS RIQFNEDFGP
LNPVYQIVNL VNQTWRTIGY WSQNNGSVID QDSIKFMGNV PSHTLFKTGL EGKHMKITTK
IESPFVNWKM SADNLEGNSR FEGFIVDLLN ELSKSLKFQF TLEVVKDNSY GGFSLISQEW
NGMVKDIIDE KADIAAGAFS ITVKRSEVID FTIPFMDQGV TILMTKPKTP PVSIFRCFAP
FNLSLWIVIG VFLIVIAILF FVVGILSPYD SFIDAVQHLP ICKRLKAEGK NNDLKNAQQK
WKDDYGEVVA SMNLGNSLWN SVSTFLQQGH DRPPTAISGR IMLGSAWLAS CIIIATYTAN
LAAFLTVENL NSEINSLQQL ASQSKVKYGT VRGSSVYNFF EHATMAPYSE MAQRLINVPN
TEAGINKTKN EDYAFLWDAA IIDYYKNKYC TLNTVGGQFR KDGYALGLRK GSPFIQEISI
AILKLRQSGY IEHTLKKWYQ KAGQCVTSKT TTSYKQIDIN HLYGVFVLTL CAAGVSCLVL
CIEWIITLQR DVDKSDPEAS KICRLKVKLD TNSHLYSMLH I
//
