ID   A0A369SIG9_9METZ        Unreviewed;       601 AA.
AC   A0A369SIG9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Amiloride-sensitive sodium channel subunit beta {ECO:0000313|EMBL:RDD46282.1};
GN   ORFNames=TrispH2_001311 {ECO:0000313|EMBL:RDD46282.1};
OS   Trichoplax sp. H2.
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD46282.1, ECO:0000313|Proteomes:UP000253843};
RN   [1] {ECO:0000313|EMBL:RDD46282.1, ECO:0000313|Proteomes:UP000253843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Panama {ECO:0000313|EMBL:RDD46282.1,
RC   ECO:0000313|Proteomes:UP000253843};
RC   TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD46282.1};
RX   PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA   Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT   "Trichoplax genomes reveal profound admixture and suggest stable wild
RT   populations without bisexual reproduction.";
RL   Sci. Rep. 8:11168-11168(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDD46282.1}.
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DR   EMBL; NOWV01000009; RDD46282.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369SIG9; -.
DR   STRING; 287889.A0A369SIG9; -.
DR   Proteomes; UP000253843; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:RDD46282.1};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        53..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          132..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..164
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   601 AA;  66332 MW;  FAAC79AEBC58FE3F CRC64;
     MPTKQLKVMS QHNGGISVRK KRLLAITVSR GFEDCGAQGI SNMARAQTTQ ARILWAILTI
     AAISLCTVMA VDLIQKYYRF EYDVTLKISF KPQLDFPVIT ICNLNPMLRS EMIKRPIFKP
     LYGRDFESVN TSQTSPLVNN SSLSNNTVGQ SDSNSSSPLP TNKVPQDATA AAAASTVAAN
     SQGGTAAGST KESGKTATPT GTKTSLPRVK KSLSKDVNEN IDRPTPPAGV QFENLDKSHE
     NYHLFSEISA ELFNRLTDQR MYELGTQASN FIAKCTFKQK PCAANFNTGN SRGKRIESVN
     YPGPLFGLQL YLDINKAEYI SREVPTAGVR IAVTPQGVRP NPEDEGFDVP PGALTSIGLK
     MRNISRLSTP YNKEGCLKHP PNNKTLNIYE NGSDRYSYKG CIKSCIASLQ NKTCGCIAAR
     YSFTSSTKGL KVCSLKNETE INCQSRLQNR FIAGKINCGC VRACNEQSFE ATTSQAQFPS
     EVNLDNNNDL LEYFKRDLTK FQLTRKTVTP FLRENLVAVN IYYEELNFET IEQTPRYSEI
     DLASDIGGVL GLWIGISVLT VFEFMEILVD SLLIIFGKEK IASRRNTITE FKAQLQASGL
     A
//