ID A0A369SII1_9METZ Unreviewed; 2093 AA.
AC A0A369SII1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE SubName: Full=Dedicator of cytokinesis protein 9 {ECO:0000313|EMBL:RDD46609.1};
GN ORFNames=TrispH2_000974 {ECO:0000313|EMBL:RDD46609.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD46609.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD46609.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD46609.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD46609.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD46609.1}.
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DR EMBL; NOWV01000007; RDD46609.1; -; Genomic_DNA.
DR STRING; 287889.A0A369SII1; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11694; DHR2_DOCK_D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF26; ZIZIMIN, ISOFORM K; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843}.
FT DOMAIN 168..274
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 642..819
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1656..2081
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2093 AA; 238216 MW; AB88BFB7422D9213 CRC64;
MAAAKISRSS ISIDHRGGAD SNKGKDDRLL VRLRQLSYPL DYEKEISSNT DHHSHDPLQF
MLNFPVDDVS AATKSRQLRT IRSTVPSNAL SEATNAFVRE TLRSYTVDWN IIRTKYNEYS
GNFTKLPTTI LRNRDTLREQ KFEIDIMDDE IDSIIVEEGI QVKLPKELVS MKGYLTIAPN
SNDTSVTLKS NRRMWFFLKT STDSSYIIEY FKGRESHLAS GSILLPESTR LAKFTYDTRQ
FGFSLQLPDM TYGLIADSLA ERDQWYDTLC KALGSEKFIE ENSDKQPNTQ RYSSLRDSLL
HSRCPDLIKY AKEIDFQNAL KRTESNRKLF SIYPDLESAE KFAQDEGLPE AVSFIEQLGT
RFILRPKELL FRLNMNIENV VSNVEPFFIS VALYNVQDNL KISEDIHFDL NHSIIRDNLP
EGEARFSNEG EEVIDGTTSG NNSGGINRNH MAVFDNRAYT YKQEAVFSVT CPSTHVYMVV
RIEKVLQGSI SACVEPYIKG ADNPKIAQRV HKQVTSICGR LGNYRMPFGW AYKPVFKNTN
GELDPQEFSP IFKQDSGKLS DEDLLKFLAD SNKIKLPTIP GHFVAVLESL GADQPENCVT
PSIQPIKPFK SQDSSLPTPV IREVDEFLTA NPKALQPHLS YYNNLYVYPI TIRFDGQKTF
ARARNLAWTV SFYDSDDVQA SALKCIYGEG MQAEFVSSIT CPVLYHNTSP SFNCSIKIAL
PVQLHSRHHL LFKLSHISVE QSKNNEKYRV ASNVGYAWLP ILQDGRIIGN EHSLPVAKKI
SPGYLSSQSL GLKRGFSGPQ EMEWVDGGRP LLKVSTSLKS TIYSQDPHFQ KFFSNYQQSN
ASTLSNVEII QLMKALHAVE LNTLIPFLPV LSNHLFRVLR RYQNADVSVT ALSVLIYMAF
KLHSAGRTEL LNSYVKYVFV ADLGHGIQNT VHEELVRNMI VIFEGRPNID PALSSKLLNY
SWFFFDIMVK SMAQYLVQTG KLKANRIFRY SDHYLNDLEE LIVAMLKQIR NKADDAPATN
CMTYMNRGFL LKIIKFYTEN LKCGDHSKTM RMKFDFLQII CSHEHYIPLN LPYEEKPPAT
FDLTDDFHKK HPLVGLLLKE VQTAMQQHDS NVRKHALKVL RNLLIKHDLD DRYNDKICQA
RIAMLYVRFF SIVFQNSHKI KASKAVIPPD SAPVSPFPSD DIGSMAPSSS CQSLTSIGRG
TTTTNTNGST ANASVFDRYA THNKSFSGTA IPVIPVQIDD GLSKDLSSSS TSLNKSAPMR
SVSSSDATAQ ERTFAKRYNS LRTSIAIATD FKQFPGHFDE RETKDILICF IYVLRNLDDG
CLFTWWRSAM AFASKHPAGQ WEIIAEKGLN NFSQLLAFFD ILGATVSCFR YVGRKSASDT
SLKVNQAKAA LEQAYATIGS SRSTSHYRGE QRAQRQSLIS NQKEVKSSGL AKAEKAILTR
TILEGNMANE IGFVVLSVLE AFCIHFKTQL EQDNGDNVLM RKVSSLLVLF LQIGQSEFLL
EHVFAAIRSF INKFPVVLFR GTSSFCATLC YEILQCCKSK LSTVRQQASL ILYLLMRSNF
EYTGRDFVRV NLQATLAISR IISGVSGNTD EGLIKSSLNQ ISSLVNSDEG MKQTLFPSQV
YNLLKRLRTV LVAMNKMQKY RDDPELLIKL QYSLAQSYVN NPQLRQYWLE QMCLTHESHG
NISEAALCQV HIAALIAEYM QRKMNYDHSC RVFTRVSNNI VEEENLQEDK AAEDVIGYTE
DLYVEMMEKC VKLLTIAERY ELVAEIYRLL LPIYERQRHF QQLADAHGQL HEAYKKIVEV
MSSGNRFLGT YYRVSFFGQE FEDDGGKEYI YKEPKVTGLS EISQRLSAMY GKRFNKEVAI
IQDSGQVDTK TLDEKKIYIQ VTFVSPYFEE EELENRITEF ERSTNLHRFM YETPFTLSGK
THGALSEQYK RKTVLTTSHF FPYIKKRLLV VQREQFELTP VEVAIDEMQN KISQLYEVIR
DPPDMKKLQL VLQGCVSVQV NAGPMAYAKT FLSPKTVHNY ARHHVEKLKS VYRLFMNLCG
DALELNGKII KEDQRKYQEQ MIHNYDEMIK DLTVVLGAEK AVPEEDVVNE ATV
//
