ID A0A369SJV6_9METZ Unreviewed; 800 AA.
AC A0A369SJV6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN ORFNames=TrispH2_000093 {ECO:0000313|EMBL:RDD47146.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD47146.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD47146.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD47146.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD47146.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD47146.1}.
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DR EMBL; NOWV01000004; RDD47146.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369SJV6; -.
DR STRING; 287889.A0A369SJV6; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16855; STAT5_CCD; 1.
DR CDD; cd14801; STAT_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046994; STAT5_CCD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|RuleBase:RU046415};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 2..127
FT /note="STAT transcription factor protein interaction"
FT /evidence="ECO:0000259|SMART:SM00964"
FT REGION 741..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 91662 MW; 2B2B6D7294EDEF27 CRC64;
MALWAASQSL RGPALQQMLQ TYEMHQFHIE IRCVFANWIE NQFWSLGQNR DELTAIRVRD
ELLSLMRQQT QQLEQISTQD ALLQWSRMTK YIEDFKNRFQ QNPMRLLDIL LDCLETERKL
CQEATITLKG NDESSNWPNG NNNISTAAED IRKICSQLHM ITIDAENDWK NIQQLRENLN
ILYHHWNKLL EEHPECRYQP VPNSKYPSSQ MQAFKQRQKL CNDIRKIVKH RKDTEMGIAE
KFAKIVEGVK VLHSKVLDVQ LFEWKQRQKA LGGIENLMNT HCEELKQIQL WCESSLDTIW
QTKILVEQLL AVCDKNLHAN DQAVKPTLDI ILQELENLLS ELVNKAFVIM KQPPQIIKVD
TKFAASVCSL IGTKLNAFSQ LTDVNAYILS ESQVRSLRSG NFPPDLGASG KILNSCKPMQ
FDSQTRMWKV DLTNMKIGRR ATAKGDEMVT ELKFAILFTS EFTIQAKKII VRDVSLPTVI
IVNTNQTANA MGTVVWDNYF SSPNREGFEV PKEVKWQSIA HMLNTEFFHR VGSGLSEENL
QFLACKLIGD SHVMKTVDLS CTVVTWQKFI KIPVSEFNQP FWKWFHTVLD LMQSNSELKA
IWCEGLFVGF IAKERAKEIL LGCEPGTFLL RFSSGKPKAI SICFTRVDRS GQKVVEFPEP
LDEKKFTLMK TLSECLFDIQ QFRYVYPKGI SKEDAFRSHY SGSGNQISCS RETAGSENGK
SSIYDKSRLK FKLFLDDSTG SEPSSTCSTP LSTPQALTPS VDHDCEMAGI NVYSEMQDVS
DDFVRHLLQG NAVDESENFN
//
