ID A0A369SKW2_9METZ Unreviewed; 910 AA.
AC A0A369SKW2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Glutamate receptor ionotropic, kainate 1 {ECO:0000313|EMBL:RDD47537.1};
GN ORFNames=TrispH2_000861 {ECO:0000313|EMBL:RDD47537.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD47537.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD47537.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD47537.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD47537.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD47537.1}.
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DR EMBL; NOWV01000002; RDD47537.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369SKW2; -.
DR STRING; 287889.A0A369SKW2; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF354; GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:RDD47537.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 430..808
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 440..501
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 910 AA; 102325 MW; 7CF5811C54746662 CRC64;
MARQRLIYLV FIGITYLMAL PLANTLLRVK IGLIVPYEAV EIGDTMKSAE DYINRILFAD
KINVSYSIVY ANISDPVDNV VKGCKVMQDG VIAVIGPLAD NMVEQLQWIF SSVHIPNIAP
LASDVSNSRS SNFQYLIRLV PPHSVMVEAV ASIFTSYGWN KAALLGSDTN FGIKSLTEFT
ILALKNRWKI LNFELFSIIS NTSTDVTLDD RLKRIKTSGA RIVILAADSR QAMDVINKAN
KLSMLESGWA WILLVDVADK DGFKLAFPVY SDGLLVVTQT AGKGQLYDDV IGRYPNLQPI
LLKYFDAALA IAYAVNNLLD DGVIIQPEGM NCIRESVDPW QHGKILLKRI NYVLSVGNEI
TYDSVSKFPF ASSLYPPNAA YEIFNFHYPN WIKVGKWTNV QRLFLDKNNT RFLGQSSIIS
DSGSAIFGKH LIVTTVIEEP FMMKNNKTGK LSGFLVELLE QLSLDLGFTY TLQFQEDGQY
GIPELTSDGV KWSGMVGSLM RREVDLAVAP LSITKERELV IDFTMPYLEN GYKMLMKRPE
YHSPSVFQCF APLRPLVWLM IAIAILLISV TVTCIHYFGP KDYVNEQLHL LPNYQYGGLP
SEQDIRNWVE DNKADIKALN LSNSVWSTLS AFLQQGTNYN PRSLPLRFIT AIWWLACTII
ISTYTANLAA FLTVNRLDPE ITSLLQLSQQ HKIKYGLPAG GSIHNHFRTL NYTPYPEMRP
HLKLVNNTNE GIKAAKKGGF VFLYDASTLN YLVTQDCSLI TTGQEFIKSS HALGLPPNSR
YTTEITLGIL NLRVNGFITK GLERWYGSKR CQNADQSPKA NYQTIGVEHL AGVFLIILCG
IVISWIILVI QWYIAAYRNF RSKSKGNMEH MKSKNILEAS RRRFDLILLI LRLMNASDSV
VTEKQTAVEV
//
