ID A0A369SLI5_9METZ Unreviewed; 2436 AA.
AC A0A369SLI5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Spectrin alpha chain, non-erythrocytic 1 {ECO:0000313|EMBL:RDD47344.1};
GN ORFNames=TrispH2_000403 {ECO:0000313|EMBL:RDD47344.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD47344.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD47344.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD47344.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD47344.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD47344.1}.
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DR EMBL; NOWV01000003; RDD47344.1; -; Genomic_DNA.
DR STRING; 287889.A0A369SLI5; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11856; SH3_p47phox_like; 1.
DR CDD; cd00176; SPEC; 12.
DR Gene3D; 1.20.58.60; -; 18.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 17.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 969..1028
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2286..2321
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2329..2364
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 300..327
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 391..457
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1133..1167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1239..1266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1588..1629
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1768..1802
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2436 AA; 280392 MW; E6459FC03AEF796B CRC64;
MSTTSASGKK KGPRLDEIKE KRERVLQRFN KFKDGSQDLK KKLEDARDFQ RFKRNVSELE
EWIDEQMKIA NDESYKDPVN IQIKVKRHED FQGVIAKQKD VLDELVKEGS DMIDNEHLFF
EQIQELLKQL LNHWEELDDK LSSKGAKLRE TQKLSAFTRE VDELLAWIAE KEAVASSDDY
GRDLEHAEFL FKKFEEVQIE VKTGELRVEH VKEVAQPLID EDHPGKETVT ERIETVIVAW
EKLLITIQIR HDKLLASVEK NRYKNAVEDA KQWIDERLAS VKDDDDPSNE ENAAAIKRKH
DRIGNEVAAI EEKVNQLQAQ ANELCDKFPD DEDEIRAGSD SLDEKWNSLK DEVNMKRLKL
NSGLNWLSLQ SRCKDYEMWA NTKKSDLAED ITKENISADV LEAQHEELKH EIRARNENLD
ELLEECDQLL VSDHQSSDSI KNKMDLLKNL REELLEDWEE RNGVIEIMAS YQEYVRGVNQ
VDSWMDKREP LLATDMPIES LDSAQALIKK HENFETTFTT QQEKAKTLYE SADKLVDENH
YATEDIVNRK NKLEKHIQDT VLKAERRRHF LDDAHQYYNF VNVAEETIQW INEQITTVSD
DSYKDLSNMQ GKLRKHQAFE AEVSANRTRI DNVNNSGKAL IEAEHPKTDK IEDKLDEING
LWDKLVRLSS DKGSKLRDAH RELLFNREVD DMERWIAEVE LQLYSEDIGR DLVSVQNLIK
KHTLLEADIA AHTEALKAIT EQADAFISEE HFHADSIKDK QQQVALRFSG LEDPVSERKA
KLNDSLLLFQ FLRDVEDEET WIREKEAIAS SGSHGRDLLT VQSLIKKHQA MQTEIDNHET
KIDAVCADGQ KLIDDEHYAT NDINDGINKL KDAWNLLKDK CIGRKSELDD SLRTHQYFAD
SSEAEQWIKD KDQLTSSTDY GKDEDSAQSL LRKHDAVLSE IEAYGETIDN LRTASSKCKD
IKPSASEVPP GTEMKALEDF DPDSSHELSL QKDDVVSVVH AANPKWWKVV KDDKVGFVPA
SILMQVSDNS SETPLSPVSS LSPTVRPRSV SRLSVSRMSM MGPVELENVA SRQQALDDRY
NALLKKARER RQKLVDSYKR HGLSREMSEL ETWIEEKKAA NTSAELGNDL DHVEALKQKF
DDFLKDLEAN ETRVNEVNEV SQKLQNEGHS DAEAIRQQTL NLLENWDNLK KLTEKRRADL
SGSHDIHKFF RDADETTSYI SEKVAVMSSD EVGRDLASVQ ALMRKHDGIE RDIAVLEDKI
QGLDVEATKL AEIHPDSAER ICAKQSEIAE AWDNLVKQAA SRKAKLTDSQ DYQQFLNDHR
DISSWINGMN SLVSSNELAH DVPGAETLLE VHLEHRTEID SRDESLQNLK NFGQSLIDKE
HYASEDISEK LSSIQVDMQQ LENNWEFRKV RLDQCLGLQM FHRDAQQAES WMSVKENFFS
TYDIAAQEDT TGSKKRENLD KAFALQEEKI NALRDMSDLL TEEGHYDAES IASKRDEILD
RWNKLKDMLE SHRSKLGQTK TLNQFNLDAD EMEGWLNDKL KSLQDDSYQD PAFVQSKLQK
QQALEAEVAA NEDRIKAVID MGNDLMANDA CSGNEEDVKK RIKDLEDQLL KLKEQMSEKN
TRLKEASVLL QFTNTVKDLD FWFVQIEVLL TGEDYGKDLV TVSNILKKHQ VLLADVEVHA
ERVEDLKKQG QDLIAGDHYG KDTIAEQIKD VADKFNKVKG LCAVRHDKLQ KSYILFQFYR
DIEDEETWIS EKKLLMGSED YGKDLTSVQN LRKNHQRFQT ELSGHDNRIK NIQETADKLL
NDESYPQADI KNRSESVSNL WMELKDAVAR RTEKLEQSYG YQQFMFDVEE EESWINEKFA
MVNSDDYGDS LATVQNLLKK HEAFETDLEI RRDRVEKTVR DGEKLVNDGH YQSDNISARC
QSLDSKLHVL INVAVTRKAG LRESHNFLQF KWKADVVESW IDDKENQIKS GDYGKDLSSV
QALITKLDTF DSGLAAFEQE GIANLTSLKD DLIDSKHAKS DDIHARHKKV ADRWENLKNL
SDDRRGRLLQ SQDKFKELED LFLTFAKKAS AFNSWYENAE EDLTDPVRCN SVEEIQALRG
KHAQFKDSLA TEKNNLQQLR DLTKKIETYT RSSNPYTWFT MDAIEDSWKN IQSIVAERDG
DLAKEEERQL QNDKLRQEFA KYANSFHTWL RETRANMVEG SGSLEDQLEN TKKISAEVTR
RKTDLKKIED LGARLEEALI LDNKYTEHTT VGLAQQWDQL DQLGMRMQHN LEQQIEARNS
SGVSEEQLNE FSTTFRHFDK DRSGKLDHAE FKSCLRSLGY DLPVVEEGEK DPEFEAILAS
VDPNGDGFVT LEEYMAFMIS RETENVASKK DVEDAFKALT ADGDKPYIIG SELYQSLTKD
QADYLVNNMP PYRNAHGDIV PDAFDYKAFT NMLFVS
//
