ID A0A369SSL3_9METZ Unreviewed; 845 AA.
AC A0A369SSL3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Low-density lipoprotein receptor-related protein 4 {ECO:0000313|EMBL:RDD47933.1};
GN ORFNames=TrispH2_000491 {ECO:0000313|EMBL:RDD47933.1};
OS Trichoplax sp. H2.
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=287889 {ECO:0000313|EMBL:RDD47933.1, ECO:0000313|Proteomes:UP000253843};
RN [1] {ECO:0000313|EMBL:RDD47933.1, ECO:0000313|Proteomes:UP000253843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Panama {ECO:0000313|EMBL:RDD47933.1,
RC ECO:0000313|Proteomes:UP000253843};
RC TISSUE=Whole clonal animals {ECO:0000313|EMBL:RDD47933.1};
RX PubMed=30042472; DOI=10.1038/s41598-018-29400-y;
RA Kamm K., Osigus H.J., Stadler P.F., DeSalle R., Schierwater B.;
RT "Trichoplax genomes reveal profound admixture and suggest stable wild
RT populations without bisexual reproduction.";
RL Sci. Rep. 8:11168-11168(2018).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD47933.1}.
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DR EMBL; NOWV01000001; RDD47933.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369SSL3; -.
DR STRING; 287889.A0A369SSL3; -.
DR Proteomes; UP000253843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:RDD47933.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:RDD47933.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 744..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 303..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 344..383
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 477..518
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 519..562
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 563..605
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 28..46
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 61..73
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 68..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 80..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 101..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 108..126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 120..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 140..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 147..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 159..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 183..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 190..208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 202..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 222..234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 229..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 241..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 348..358
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 845 AA; 93075 MW; 6F6C6A4E804B32F3 CRC64;
MPGIVETHQP AKQRTAQVTC HPNNEFTCND GKCITTSWVC DGQNDCIDGS DEGSHCLTKT
CTPDEFSCGN GVCIKRDYVC DQVDDCGNSA DERNCTKVAT CSPQQFTCNN SHCINSAWRC
DNDNDCGDNS DEWNCPNKTC GPELFQCSSG DCIKKSWLCD GERDCTDGSD EKNCSTSRPK
HTCRAGEFQC KNWECIKSEW RCDGSTDCTD GSDELGCNKT TCKSGQFRCS AHICIDAHNV
CDGISDCANS RDEQNCTTPT PPNLTCNSSQ FTCHTNKSCI SMKLVCNGKF DCEDKSDEPA
TCNINECSEY NGHCSQNCVN TKVGYYCACN PGYTLDTDGR TCLDINECNI SNPCSQMCEN
TKGSYKCTCA DGYRLDADFK SCKALGPEPV LFFANRRDIH RFTIKGSRYN DVMKGLKGAI
GIDVHVRKRL LFWTDIVSEK IGRVTLHSNG TVAGKNKYII SDGVLSPECV AVDWIHDTIY
WTDTGLDAIK MSDLDGRYVK TIISNIADPR GLAVDPVDGY IYFTDWGSSA KIERAKLDGT
QRQILVSTNV EWPNGLTIDY PQRKMYWVDG KHHHIESANL DGSGRRVILS KGIPHPFSIT
VFENSVYWTD WESKTVETAN KLTGANRSVL LSDLYAPMGI TTFQLQRQPR HYDACHLNKG
GCSQICVKTG DYKRTCLCKD GWQLDSDGTG CVLLPTQSYN CKSIDCGYGS CLINSTNGVP
YCSCSVGYGG DNCTVITSAS TGEAMTIGVA AGCAIGFLII IIIIGYIVRR RHGKNKKTFD
EFDIQSMTNR AMINETTEDI SKRPVNNSRP VSLAISNGNF SYSSRQHLVG SRFSMVSSQS
VATQV
//
