ID A0A369THW1_9RHOB Unreviewed; 733 AA.
AC A0A369THW1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:RDD64939.1};
GN ORFNames=DU478_17195 {ECO:0000313|EMBL:RDD64939.1};
OS Thalassococcus profundi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassococcus.
OX NCBI_TaxID=2282382 {ECO:0000313|EMBL:RDD64939.1, ECO:0000313|Proteomes:UP000253977};
RN [1] {ECO:0000313|EMBL:RDD64939.1, ECO:0000313|Proteomes:UP000253977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAS1 {ECO:0000313|EMBL:RDD64939.1,
RC ECO:0000313|Proteomes:UP000253977};
RA Yu M.;
RT "Thalassococcus profundi sp. nov., a marine bacterium isolated from deep
RT seawater of Okinawa Trough.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDD64939.1}.
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DR EMBL; QPMK01000016; RDD64939.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369THW1; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000253977; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000253977}.
FT DOMAIN 328..506
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 510..605
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 733 AA; 78729 MW; 26BCCFC6A996846F CRC64;
MTDFTMIKGD DGVAIITWDV PGKSMNVLSM QGLRDLDALM DEALADDAVK GIVITSGKDS
FAGGMDLNVI AKMKSDAGDE PERGLFEGIM QMHAALRKIE LAGMDPKTLK GGKPVAAALP
GTALGIGLEI PLATHRIFCS VNPKAKIGLP EIMVGIFPGA GGTTRMVRKL GAMAASPFLL
EGKLSDPMKA KSAGIIDEVV ADPLEAAKEW VLNAKDADLV KPWDAKGYKM PGGAPYHPAG
FMTFVGASAM VHGKTQGVYP AAKALLSAVY EGALVPFDTA LKIEARWFTN VLMNPSSGAM
IRSLFINKEA LEKGAVRPAD VADQRVRKVG VLGAGMMGAG IALVSAQAGI DVVLLDQKQE
AADKGKAYSA SYMDKGIQRK KATEESKEAL LGRIHATTDY AALRDCDLIV EAVFEDPRIK
AEVTQNVEKV IPEDCIFATN TSTLPITDLA GASSRPEQFI GIHFFSPVEK MMLVEIIKGK
ETGDRAVAKA LDFVRQIRKT PIVVNDARFF YANRCIIPYI NEGMRMVAEG VAPALVENAA
RMVGMPLGPL QLVDETSIDL GAKIARATKA AMGDAYPDGA VDEVIFWMEG QERLGRKSNA
GFYSYDDKGK RQGLWSGLGE KYAPLDDQPD LIEVQHRLLF AQVLEAVRAL EEGVLMDIRE
GDVGAILGWG FAPWSGGPFS WLDIIGAPYA AERCDQLTEK FGDRFACPAL LREMADKGQS
FYGRFGQDAD KAA
//
