ID A0A370AWC8_9SPIO Unreviewed; 253 AA.
AC A0A370AWC8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Precorrin-4 C(11)-methyltransferase {ECO:0000313|EMBL:RDG33900.1};
DE EC=2.1.1.133 {ECO:0000313|EMBL:RDG33900.1};
GN Name=cobM {ECO:0000313|EMBL:RDG33900.1};
GN ORFNames=DV872_03045 {ECO:0000313|EMBL:RDG33900.1};
OS Oceanispirochaeta sp. M1.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Oceanispirochaeta.
OX NCBI_TaxID=2283433 {ECO:0000313|EMBL:RDG33900.1, ECO:0000313|Proteomes:UP000253869};
RN [1] {ECO:0000313|EMBL:RDG33900.1, ECO:0000313|Proteomes:UP000253869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M1 {ECO:0000313|EMBL:RDG33900.1,
RC ECO:0000313|Proteomes:UP000253869};
RA Yadav S., Villanueva L., Damste J.S.S.;
RT "Draft genome sequence of Oceanispirochaeta sp. strain M1.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDG33900.1}.
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DR EMBL; QQPQ01000003; RDG33900.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370AWC8; -.
DR OrthoDB; 9815856at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000253869; Unassembled WGS sequence.
DR GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11641; Precorrin-4_C11-MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01465; cobM_cbiF; 1.
DR PANTHER; PTHR45790:SF4; COBALT-PRECORRIN-4 C(11)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:RDG33900.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253869};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RDG33900.1}.
FT DOMAIN 2..207
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 253 AA; 27407 MW; 4A8409B76111D1F9 CRC64;
MKVVFIGAGP GDPDLITVKG SKVLAKALVV IYAGSLVSPE ILTWCAASPE IMDSAGMDLE
QVCQVYKEHQ NEEGIIARVH TGDPSLYGAI QEQMDYLRSE NIPFEIIPGV SSFQAAAAAL
EQEYTLPGIS QSLIITRAAG RTPVPEKENL KVLAKAGTTM VLFLSISLID KAVEDLQDSY
SADTPAAVVY RASWPDQKII RGTLSAIPQL VKDAGITRQA LVIIGDVLKG EYEMSKLYDP
SFSHGWRKGR KDN
//
