ID   A0A370AWD8_9ACTN        Unreviewed;       383 AA.
AC   A0A370AWD8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Isopropylmalate synthase {ECO:0000313|EMBL:RDG32429.1};
GN   ORFNames=DVH02_32400 {ECO:0000313|EMBL:RDG32429.1};
OS   Streptomyces corynorhini.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2282652 {ECO:0000313|EMBL:RDG32429.1, ECO:0000313|Proteomes:UP000253741};
RN   [1] {ECO:0000313|EMBL:RDG32429.1, ECO:0000313|Proteomes:UP000253741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AC230 {ECO:0000313|EMBL:RDG32429.1,
RC   ECO:0000313|Proteomes:UP000253741};
RA   Dunlap C.;
RT   "Streptomyces species from bats.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDG32429.1}.
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DR   EMBL; QQNA01000364; RDG32429.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A370AWD8; -.
DR   OrthoDB; 9803573at2; -.
DR   Proteomes; UP000253741; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42880; HOMOCITRATE SYNTHASE; 1.
DR   PANTHER; PTHR42880:SF1; ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000253741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          14..271
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   383 AA;  41510 MW;  C247C47582C6C094 CRC64;
     MVKAERRERA PSPPRISDAT LRDSAHMAGV EFGPEDAAAI AELLVRTGVE LVEVGMVSGP
     DSKDTDLVLA THEAVGPERS MTLVVVRDRR QVARALDEAE RLGVRHLMYS IPTSEAHARL
     KLDSASPKYV EKLARSAITQ AKDRGFHVTF SGEDGARTPK ERLVPYVTAG FEAGADRFRI
     AETVAYLSPW QMEEVVADLV AIDGSEIEIH SHNMLGMAVA NSLAAVRAGA QWISATVGGI
     GERGGNAPLA ELLTSLRVIH GDTRFDLTHL TELSRIALRG AGLGDAFQSG PTTPHAFSYE
     LPGQLSHPEA YETLPAELVG NTRELRVRSR LTPALVTWAL ADSGLLVDVD AFTPWLVQRQ
     ERAGRPLLDR DAIRKAAVEF RPA
//