ID A0A370B8E0_9ACTN Unreviewed; 448 AA.
AC A0A370B8E0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:RDG38078.1};
DE Flags: Fragment;
GN ORFNames=DVH02_11050 {ECO:0000313|EMBL:RDG38078.1};
OS Streptomyces corynorhini.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2282652 {ECO:0000313|EMBL:RDG38078.1, ECO:0000313|Proteomes:UP000253741};
RN [1] {ECO:0000313|EMBL:RDG38078.1, ECO:0000313|Proteomes:UP000253741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AC230 {ECO:0000313|EMBL:RDG38078.1,
RC ECO:0000313|Proteomes:UP000253741};
RA Dunlap C.;
RT "Streptomyces species from bats.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDG38078.1}.
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DR EMBL; QQNA01000074; RDG38078.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370B8E0; -.
DR Proteomes; UP000253741; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000253741};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 34..448
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 448
FT /evidence="ECO:0000313|EMBL:RDG38078.1"
SQ SEQUENCE 448 AA; 47876 MW; B9CC36EC6F7316E4 CRC64;
MASNEEKLRD YLKLVTADLR QTRKRLQEIE EQQQEPIAIV GMGCRFPHGA DTPEEMWRLL
ASGTDAVTPF PTDRDWDLDA LYDPDPDQPG TSYVREGGFL HEAPLFDAEF FEISPREAQA
MDPQQRLLLE TSWEAVERAG IVPAALRATR TGVFVGAISQ DYQPRSKEAQ ADLGGHILTG
STTSVASGRI AYTLGLEGPA VTVDTACSSS LVALHLAVRS LRSGECDLAL GGGVTVMSGP
EMFVDFGRQR ALAADGRCRA FSAAANGFGP AEGTGMLLLE RLSDARRNGH PVLAVIRGSA
VNQDGASNGL TAPNGPAQER VIRDALTDAG LTGPDIDAIE AHGTGTPLGD PIEAEALLAT
YGSARPEDRP LWLGSIKSNI GHTQAAAGVA GIIKLVLSLH HDVLPRTLHA DEPSPHIDWT
AADLRLLTDE QPWPAHADRP RRAAVSSF
//
