ID A0A370BA52_9ACTN Unreviewed; 743 AA.
AC A0A370BA52;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=MMPL family transporter {ECO:0000313|EMBL:RDG37269.1};
GN ORFNames=DVH02_15380 {ECO:0000313|EMBL:RDG37269.1};
OS Streptomyces corynorhini.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2282652 {ECO:0000313|EMBL:RDG37269.1, ECO:0000313|Proteomes:UP000253741};
RN [1] {ECO:0000313|EMBL:RDG37269.1, ECO:0000313|Proteomes:UP000253741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AC230 {ECO:0000313|EMBL:RDG37269.1,
RC ECO:0000313|Proteomes:UP000253741};
RA Dunlap C.;
RT "Streptomyces species from bats.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDG37269.1}.
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DR EMBL; QQNA01000112; RDG37269.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370BA52; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000253741; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253741};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..743
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039200947"
FT TRANSMEM 186..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..335
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 66..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 77167 MW; C275CBB35E1E486D CRC64;
MAALARWCVH HRLLAVLLWL FALGGVSAAA LASGSSYSSD YEVPGTESGE ATELLDSGFP
GLGGDGDTIV WHTGEGDTPG SRPYASVRAT EVELRTGEML GKVAKLPGVV SVVSPYSAEG
QAQISADGRT AYARVTFDRP ADAVPAASAR ALVDTAKAAG TPGLDIELGG SAVALTESTT
THTAEIVGVA VAAVVLFLAF GSFAASLLPL ATALVSVGTA YAGIVLLGRV MTVADFAPML
GLLIGLGVGI DYALFIVTRH RKGLSRGLSV REAATDAVAT TGRAVVFAGA TVCIALLGML
ILRLNFLNGV AVAASLTVVL TVAASVTLLP ALLSFIGTRA LSRRQRARLA AHGPVTDQPA
GFAARWSLLV ERRPRLLGAV AVVVMLVLAL PAFSLRLGTS DQGNNPSTAT TRKAYDLLAD
GFGPGVNGPL TLVARLDGAG DRLAMDQLPD TLRGTEGVAS VGPIMFNGSG DRALLTVVPD
SAPQARRTSE LVDRLRTEVL PRGGSGTTLK VYVGGVTASY DDFAAIIVGK LPLFVGVVIA
LGCLLLLLAF RSVGIPLKAA LMNVAAVASS FGIVVAVFQW GWGSELLGLG SAGPIEPFLP
VIMVSVLFGL SMDYQVFLVS RMYEEWLATG DNRRAVRVGL AETGRVINSA AVIMISVFLA
FVLSGDRVIA MFGVGLAAAV ALDAFVLRTL LVPALMHLLG GANWWLPRRV DRWLPRISVE
GPECRGPVAI PEARERARTP LVR
//
