ID A0A370DCQ2_9GAMM Unreviewed; 729 AA.
AC A0A370DCQ2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=DIZ80_10255 {ECO:0000313|EMBL:RDH82653.1};
OS endosymbiont of Galathealinum brachiosum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; sulfur-oxidizing symbionts.
OX NCBI_TaxID=2200906 {ECO:0000313|EMBL:RDH82653.1, ECO:0000313|Proteomes:UP000254266};
RN [1] {ECO:0000313|EMBL:RDH82653.1, ECO:0000313|Proteomes:UP000254266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A1464 {ECO:0000313|EMBL:RDH82653.1};
RX PubMed=30022157;
RA Li Y., Liles M.R., Halanych K.M.;
RT "Endosymbiont genomes yield clues of tubeworm success.";
RL ISME J. 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDH82653.1}.
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DR EMBL; QFXC01000011; RDH82653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370DCQ2; -.
DR Proteomes; UP000254266; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000254266}.
FT DOMAIN 8..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..569
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 729 AA; 82587 MW; AC9375E9592836AB CRC64;
MDVSHILDGL NDAQREAVTA PPGPMLILAG AGSGKTRVLV HRMAWLIQVE NVSPFSVMAV
TFTNKAASEM RARVEQLQGI TPNGMWVGTF HGIAHRLLRA HWKEANLPQQ FQILDSDDQY
RMIRRVLKSL ELDEARWVPR QIQGFINGRK DEGLRPQHVD AGSDPIRQQL VSIYTAYEAA
CKRAGVIDFA ELLLRSLELI RDNEELHKHY RNRFQHILVD EFQDTNTIQY AWIRLLSADK
NGRGAQLFVV GDDDQAIYGW RGAKVENILS FNNENPNTLV IRLEQNYRST GNILKAANGL
ISHNDDRMGK QLWTDGEEGN LIQLYAAFNE QDEARYVIDR IVEHVSNGNA RDDIAILYRS
NAQSRVFEEQ LMTHGIPYRV YGGLRFFERA EIRDALNYLR LLNNRNDDPA FERVVNQPTR
GIGNKTVDTI REAARLADVS MWQASLELIA SNSLTARAQN ALNGFIQLIN NLNTDTEAVE
LHEQFEHVIH GSGLIEHYGK EKGEKAEARV ENLEELVSAA KGFQFEQDED APLDILTAFL
THAALEAGEG QAEAWEDCVQ LMTLHSAKGL EFPLVFMCGM EEGLFPHQRS AEEEGRLQEE
RRLCYVGITR ARDQLVLSYA EQRRLYGKEM YPMPSSFIGE IPAEFIEEIR PKTSYSSNTS
SYGQKSDYSF AQQDNDSGLT IGQRVLHQKF GEGFVLNYEG QGKSARVEVN FDHAGSKWLV
LSYANLQTV
//
