ID A0A370EMV4_9FLAO Unreviewed; 429 AA.
AC A0A370EMV4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=DEU42_10679 {ECO:0000313|EMBL:RDI11145.1};
OS Flavobacterium sp. AG291.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2184000 {ECO:0000313|EMBL:RDI11145.1, ECO:0000313|Proteomes:UP000254305};
RN [1] {ECO:0000313|EMBL:RDI11145.1, ECO:0000313|Proteomes:UP000254305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG291 {ECO:0000313|EMBL:RDI11145.1,
RC ECO:0000313|Proteomes:UP000254305};
RA Venturi V.;
RT "Genome sequencing of rice bacterial endophytes.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDI11145.1}.
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DR EMBL; QQAR01000006; RDI11145.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370EMV4; -.
DR Proteomes; UP000254305; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Reference proteome {ECO:0000313|Proteomes:UP000254305};
KW Transferase {ECO:0000256|RuleBase:RU003423, ECO:0000313|EMBL:RDI11145.1}.
FT DOMAIN 1..68
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 113..153
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 429 AA; 45855 MW; 4ED9B18335FD1140 CRC64;
MGESVAEATI TNWLKNVGDH IAADEAVLEI ATDKVDSEVP SEVSGTLTEI LFNVNDVVQV
GQTIAYIETE GGVVVDAPKE ETTVANVQVI EKSVEAAANA VAAPVDFSGS DKFYSPLVKN
IAKEEGISLA ELEAINGSGK EGRVTKNDIL DYVKNRGSQP APVTAPAAPQ TIQQSATNNQ
QPVAAKAAPV SVNGGDEIVE MDRMRKLISG YMVQSVQTSA HVQSFIEVDV TNIVKWRDKV
KNAFEKREGE KLTFTPIFME AVAKALKDFP GMNISVDGEF IIKKKNINLG MAAALPNGNL
IVPVIKNADQ LNLVGMAKAV NDLGNRAKAG KLKPDDTQGG TYTVTNVGTF GSVFGTPIIN
QPQVGILALG AIRKVPAVIE TPDGDFIGIR QKMFLSHSYD HRVVDGALGG SFVKRVAEYL
EAFDVNRDY
//
