ID   A0A370EX48_9FLAO        Unreviewed;       886 AA.
AC   A0A370EX48;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Topoisomerase-4 subunit A {ECO:0000313|EMBL:RDI14518.1};
GN   ORFNames=DEU42_102215 {ECO:0000313|EMBL:RDI14518.1};
OS   Flavobacterium sp. AG291.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=2184000 {ECO:0000313|EMBL:RDI14518.1, ECO:0000313|Proteomes:UP000254305};
RN   [1] {ECO:0000313|EMBL:RDI14518.1, ECO:0000313|Proteomes:UP000254305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AG291 {ECO:0000313|EMBL:RDI14518.1,
RC   ECO:0000313|Proteomes:UP000254305};
RA   Venturi V.;
RT   "Genome sequencing of rice bacterial endophytes.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDI14518.1}.
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DR   EMBL; QQAR01000002; RDI14518.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A370EX48; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000254305; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RDI14518.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254305};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          37..471
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          864..886
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          436..463
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        19..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  100585 MW;  43B587E436B9D4AC CRC64;
     MDEEEDINFE PSNGEGEGNG DHFYDKEENP ESGDTITKVT GMYKDWFLDY ASYVILERAV
     PAIEDGFKPV QRRIMHSLKE LDDGRYNKVA NVVGHTMQYH PHGDASIGDA MVQIGQKDLL
     IDTQGNWGNI LTGDGAAASR YIEARLSKFG LEVLYSPKIT PWQLSYDGRR NEPINLPVKF
     PLLLAQGAEG IAVGLSTKVL PHNFNELIDA SIKILKNKPF TLFPDFPTAG IADVSNYNDG
     MRGGRVRVRA KISQLDKSTL VITQIPFSTN TTTLIDSILK ANEKGKIKVR KIEDNTAADV
     EILIHLPAGV SPDKTIDALF AFTGCETSVA PLGCVIEDHK PRFIGVSDML KISTNRTVDL
     LKRELEIQLD ELEESWHFQS LERIFIENRI YRLIEEEETW EGVIKAIDEG LKPHTKHLRR
     AVTEEDIVRL TEIRIKRISK FDIDKAQEKI EALEGEIEQV KYNLDHIIDF AVDYFQGLKD
     RYGKGRERKT ELRSFDNIEA TKVVLRNTKL YVNREEGFVG TGLKKDEYVA ECSDIDDVIV
     FLRDGSMMIT KVDVKTFVGK DIIHVAVFDK NDKRTIYNMI YRDGKSGPSY IKRFNVSGVT
     RDKPYDLTQG NKGSQVLYFS GNPNGEAEVV TILLRQVGSV KKLKFDLDFA DMAIKGRASR
     GNTVTKYPIK KIELKEKGIS TLKPRRVWFD DTVHRLNVDG RGELLGEFRP NDRLLIINQS
     GKLKTIIPEL TTHFDEDMIK LEKWNPKKPI SAIYYDGEKE RYYVKRFLVE NENKEETFIT
     EHDNSQLEIV STDYRPVAEV IFAKVKGVQK DNITVDLENF IAVKGIKALG NQLTTDKVKQ
     INLLDPLPYE EPEEEIPEEI EVSGDTEVEE TNTTLEDDGQ ITLSLD
//