ID A0A370GGZ3_9NOCA Unreviewed; 264 AA.
AC A0A370GGZ3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Manganese transport regulator {ECO:0000256|ARBA:ARBA00032593};
GN ORFNames=DFR68_12371 {ECO:0000313|EMBL:RDI42937.1};
OS Nocardia mexicana.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=279262 {ECO:0000313|EMBL:RDI42937.1, ECO:0000313|Proteomes:UP000255355};
RN [1] {ECO:0000313|EMBL:RDI42937.1, ECO:0000313|Proteomes:UP000255355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44952 {ECO:0000313|EMBL:RDI42937.1,
RC ECO:0000313|Proteomes:UP000255355};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC {ECO:0000256|ARBA:ARBA00007871}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDI42937.1}.
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DR EMBL; QQAZ01000023; RDI42937.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370GGZ3; -.
DR STRING; 1210089.GCA_001613165_07382; -.
DR OrthoDB; 9791355at2; -.
DR Proteomes; UP000255355; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 2.30.30.90; -; 1.
DR Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR007167; Fe-transptr_FeoA.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR PANTHER; PTHR33238:SF7; TRANSCRIPTIONAL REGULATOR MNTR; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR Pfam; PF04023; FeoA; 1.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00899; FeoA; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Reference proteome {ECO:0000313|Proteomes:UP000255355};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 49..111
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50944"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 28704 MW; E00CED68F6987580 CRC64;
MHKLGNVPGK RDIATRRELV DPSATQESDG ENGSEAADTS SEDTLAPVLS SVAQDYLKVI
WTAQEWSQEK VSTKLLAERI GVSASTVSEA VRKLADQGLV EHARYGSITL TDLGRRAAVA
MVRRHRLIET FLVNELGYGW DEVHDEAEVL EHAVSETLMA RIDAKLGHPD RDPHGDPIPS
ADGAVPTPPA RQLSHFQAGE SGRVARISDF DPAMLRYFDS VGIALDTPIS VVERRDFAGT
IAIRIGDRTI DLGSPAADAI WLIH
//
